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Ian Bosdet has been at 22 events

HostFollowersTitleDateGuestsLinks
Joanne Manaster113,609Join Joanne and Jeff for Read Science this Thursday, April 30, at 2pm EDT as we talk about the science of cancer with Sue Armstrong, author of p53, The Gene that Cracked the Cancer Code, and George Johnson, author of The Cancer Chronicles (and also of The Ten Most Beautiful Experiments)Science Books2015-04-30 20:00:0017  
Joanne Manaster113,609In this episode of Read Science! Jeff and Joanne will be hanging out with our favorite lover of the periodic table, Theo Gray and photographer Nick Mann, to talk about the new book, Molecules: the Elements and the Architecture of Everything! If you enjoy Theo's columns in Popular Science and the book The Elements, be sure to join us this Thursday, October 16th at noon EDT for this Google Hangout on Air!Read Science! Molecules Edition with Theo Gray and Nick Mann2014-10-16 18:00:0029  
Joanne Manaster113,609Join Jeff and Joanne on Read Science! as they are joined by the Kitchen Pantry Scientist herself, @110768492090057570044 to talk about teaching science concepts to children with things you have at your house! There may even be live demonstrations. Questions will be accepted from the audience. Thursday, September 25, 7pm EDT.Read Science! Kitchen Science Lab Episode2014-09-26 01:00:0032  
Science on Google+659,719Please join us for _Developmental Science HOA_, a new collaborative Hangout On Air series which is co-hosted by @105917944266111687812 and @101300484336332917485. In the first Developmental Science HOA we will be talking with Dr. @105599496459565727178. @105599496459565727178 is a Professor of Cognitive Science and Human Development at @117506114004660150074 and is the director of the @113073858999174005281. @105599496459565727178 studies the dynamics of infant social interactions and social learning, using experimental behavioral paradigms, ethnographic investigations, physiological studies, and computer simulations. He and his collaborators conducted the first study of real-time interactions between parents and toddlers with high-density EEG and motion capture of both participants. He also studies how children learn and use words, and how they flexibly shift their attention, representations, and inferences. *Important Links* Curriculum Vitae: http://goo.gl/qLtUaC Lab Website: http://goo.gl/AQ78h6 ResearchGate: http://goo.gl/Mj8deH *Relevant Papers* Watch the hands: infants can learn to follow gaze by seeing adults manipulate objects: http://goo.gl/bSMzKy Young children’s fast mapping and generalization of words, facts, and pictograms :http://goo.gl/nhykZF A Unified Account of Gaze Following: http://goo.gl/f14c04 Micro-analysis of infant looking in a naturalistic social setting: insights from biologically based models of attention: http://goo.gl/i0S8uA Visual Prediction in Infancy: What is the Association with Later Vocabulary? :http://goo.gl/I1xUaS Please note that some of the papers are behind a paywall. Manuscripts can be downloaded through the lab pubs page, http://www.cogsci.ucsd.edu/~deak/cdlab/publications.html.Science HOAs2014-08-05 18:00:00103  
STEM Women on G+172,761Join us for a STEM Women HOA as we speak to Professor @102683355993519058911  on her career as a materials scientist. Julia works on 3D nanomaterials, and her research specialises in the creation of extremely strong yet ultra-light materials. She will talk to us about her fascinating career path and diverse interests, along with ways in which academia can be more supportive of STEM parents.  This HOA will be hosted by Dr @108510686109338749229  and Dr @110756968351492254645    and you can tune in on Sunday June 22nd at 2.30 PM Pacificl/ 10.30PM UK. The hangout will be available for viewing on our YouTube channel (http://www.youtube.com/stemwomen) after the event.In the Spotlight, with Professor Julia Greer2014-06-22 23:30:0032  
Joanne Manaster113,609Join @104733415626297507218  and +Joanne Manaster for this episode of @115923395996980624785 where their guest @109710318485682657052 tells us all about teaching the general public a bit of physics here and there. Oh, and all dogs are welcome!   Thursday, June 19, 2014 at 12:30pm EDT, 11:30 CDT --About one hour longRead Science! "My Dog Knows Physics" Episode2014-06-19 19:30:0035  
Pamela L. Gay87,867Join us to talk with Moon pioneers @100178094478432687792 and @101857647439433066235  and find out how they're engaging students -- and heading to the Moon! Overview A global team of scientists and engineers are all working toward constructing missions to land on, travel across, and send video back from the Moon. With this new Google Hangout on Air series, we will introduce you to the men and women behind each of these planned missions and bring you all the latest developments from the +Google Lunar XPRIZE .Google Lunar XPRIZE Team Hangout 005: Rockets and Students ENGAGE!2014-05-28 03:00:4824  
STEM Women on G+172,761Join us for a STEM Women HOA as we speak to  @112565301103246592411 on her career as a primatologist. Erin is a graduate student in physical anthropology who recently returned to Ohio after an extended field trip. She will talk to us about her recent experiences in the field working with Diana monkeys, her exciting career path as a woman in STEM, what inspires her, and why supporting women in STEM is important.  This HOA will be hosted by Dr @108510686109338749229  and Dr @110756968351492254645   and you can tune in on Sunday May 25th at 4.30 PM Central/ 10.30PM UK. The hangout will be available for viewing on our YouTube channel (http://www.youtube.com/stemwomen) after the event.In The Spotlight, With Erin Kane2014-05-25 23:30:0053  
Science on Google+659,719Join us for a Science on Google+ HOA as we speak to @103606144980849672198 and Dr @106260309299618873309 about their recently published research on cancer signalling (http://stm.sciencemag.org/content/6/225/225ra28). We will discuss the basics of cancer signalling, explain the link between inflammation and cancer, and how their research identifies a novel role for immune cells in the development of colon cancer. This Pub Talks HOA will be part of a series in which we explain published research in a jargon-free manner that is understandable to the public. This HOA will be hosted by Dr @108510686109338749229 and you can tune in on Sunday March 23rd at 2 PM CDT/ 12PM PDT/ 7 PM GMT. The hangout will be available for viewing on our YouTube channel (https://www.youtube.com/ScienceHangouts) after the event.Pub Talks: Cancer Signalling2014-03-23 20:00:0086  
STEM Women on G+172,761Join us for a STEM Women HOA as we speak to Dr.  @103389452828130864950 on how men can help with the issues of gender inequality in STEM fields. Yonatan is the Chief Architect of Google+ and also has a PhD in Physics with a strong engineering background. He is a passionate advocate of gender equality in STEM, and will talk to us about what we can do to encourage women in STEM. This HOA will be hosted by Dr @108510686109338749229   and Dr @110756968351492254645  , and you can tune in on Sunday March 2nd at 12.30 PM Pacific/ 8.30PM GMT. The hangout will be available for viewing on our YouTube channel(http://www.youtube.com/stemwomen) after the event. Follow us on Twitter @stemwomen and on www.stemwomen.netSTEM Women: How Men Can Help with Dr Yonatan Zunger2014-03-02 21:30:0097  
Science on Google+659,719Can you believe it! The +Science on Google+ community is approaching 200k members! We'll have reached that number by this weekend, so we're going to have a huge community celebration! Join your hosts +Scott Lewis and +Buddhini Samarasinghe as they start the celebration of being the #1 science community and the #10 community in *all of Google+*!!  During our Hangout On Air, you'll get a chance to meet the moderators  who dedicate so much time and energy into making sure that good, high quality science content is showcased in the community.  After we hear from the moderators on *who* they are, we'll have a discussion on what the curator team looks at for community posts to get put on the *Curator's Choice*.  We are all extremely excited to be celebrating with all 200,000 of you! Let's stay curious and find new and better ways to understand this amazing Universe we all live in! #ScienceSunday   #STEM   #ScienceEveryday   #SoGp200k  200,000 member community celebration!2014-01-12 22:00:00183  
Science on Google+659,719*Isaac Newton's Birthday is on Christmas* Join us in a Newton-inspired holiday physics hangout with rockstar physicist +Henry Reich of +MinutePhysics and +MinuteEarth  and brilliant ballerina biologist +Carin Bondar of +National Geographic, +Scientific American and host of Wild Sex, a science show about the strange reproductive habits of the animal kingdom. She knows how the world gets physical. +Veritasium  AKA +Derek Muller may pop in.  We hear there may even be more special guests so you should probably go ahead and RSVP yes to join the lively conversation. BYOB. Hosted by +Amy Robinson of +Science on Google+ .Happy Newtonmas Hangout2013-12-19 00:00:00144  
Science on Google+659,719Join mathematicians Dana Ernst , Sara Del Valle , Vincent Knight , Luis Guzman  and Robert Jacobson  as they talk with Amy Robinson  about their favorite math gifs and ideas and what it's like to be a mathematician. How many numbers are there? Do mathematicians see the world differently? And why is the last panel of this xkcd comic funny? http://xkcd.com/804/ +Dana Ernst   is an assistant professor in the Department of Mathematics and Statistics at Northern Arizona University in Flagstaff, AZ, USA.  +Sara Del Valle   is a mathematical epidemiologist at Los Alamos National Laboratory in Los Alamos, NM, USA. +Vincent Knight   is a LANCS lecturer at the Cardiff University School of Mathematics in Operational Research in Cardiff, Wales, UK. +Luis Guzman   is a graduate student in mathematics at the University of West Florida in FL, USA. +Robert Jacobson   is Assistant Professor of Mathematics at Roger Williams University in RI, USA. Hangout hosted by Science on Google+'s +Amy Robinson Math: from GIFs to xkcd2013-11-22 02:00:0064  
Imagine Science Films623,293On September 25 at 11AM (EST), #Experimenta invites the legendary +Carl Zimmer  for a discussion about the marriage between science and moving images and his Jury Emeritus status at Imagine Science Films. Join us for a dissection into the raw matter that makes up scientific movie-making.Into The Dark Matter of Scientific Movie-Making With Carl Zimmer2013-09-25 17:00:0038  
Science on Google+659,719Posterside Hangouts is a new Hangouts On Air, which is hosted by the Science on Google+ Community (http://goo.gl/uhJCN). The main goal of this HOA series is to recreate a poster session-like atmosphere here on G+, so researchers can present their recent findings. Presentations will be grouped by discipline and individual presentations will last approximately 10 – 15 minutes. Do you have a recent conference presentation, manuscript, or book that you would like to share with the Google+ community? Do you want to give your undergraduate or graduate students practice presenting their research? If yes, then let us know by filling out this short form: http://goo.gl/e0KPhE. ================================ *Psychology Talks for Posterside Hangouts #1, Authors (Affiliations)* _When audition dominates vision: Evidence from cross-modal statistical learning_ +Chris Robinson (The Ohio State University at Newark) _Automatic selection of eye tracking variables in visual categorization for adults and infants_ +Samuel Rivera (The Ohio State University at Columbus) _Foreign accent does not influence cognitive judgments_ +Andre L. Souza (Concordia University) and +Art Markman (The University of Texas at Austin) _Positive mood may enhance cognitive flexibility: Evidence from category learning_ +Paul Minda (The University of Western Ontario) and +Ruby Nadler(The University of Western Ontario) _The effects of aging on face perception_ +Allison Sekuler (McMaster University) ================================ *Abstracts and Links* _When audition dominates vision: Evidence from cross-modal statistical learning_ Presenting information to multiple sensory modalities sometimes facilitates and sometimes interferes with processing of this information. Research examining interference effects shows that auditory input often interferes with processing of visual input in young children (i.e., auditory dominance effect), whereas visual input often interferes with auditory processing in adults (i.e., visual dominance effect). The current study used a cross-modal statistical learning task to examine modality dominance in adults. Participants ably learned auditory and visual statistics when auditory and visual sequences were presented unimodally and when auditory and visual sequences were correlated during training. However, increasing task demands resulted in an important asymmetry: Increased task demands attenuated visual statistical learning, while having no effect on auditory statistical learning. These findings are consistent with auditory dominance effects reported in young children and have important implications for our understanding of how sensory modalities interact while learning the structure of cross-modal information. Link to Poster: http://goo.gl/NfoMvg Link to Manuscript: http://goo.gl/VFBVkD  Personal Website: http://goo.gl/glUXv2 _Automatic selection of eye tracking variables in visual categorization for adults and infants_ We present a computational apScience on Google+ Posterside Hangouts #12013-08-13 02:30:00100  
Science on Google+659,719*Be curious. Question assumptions. Explore the world from atoms to astrophysics with Veritasium*. Join +Derek Muller of popular +YouTube Channel Veritasium on a journey to the beautiful, viral side of physics, hosted by Science on Google+ in honor of *YouTube Geek Week* (Aug 4-10). Our +Amy Robinson, +Jason Davison and +Nic Hammond will host, along with +Joe Hanson of +It's Okay To Be Smart and a few members of the community who ask Derek interesting questions on the event page.   The hangout happens on *Wednesday, August 7th at 5 pm US PT / 8 ET*. Derek will share why he creates Veritasium and how it has evolved into one of YouTube’s favorite sources of answers to epic science questions. He’ll also answer your questions so leave them here on the event page. You may be selected to join the hangout live and ask him in person.   Check out *Veritasium* on YouTube at http://veritasium.com   This is the third hangout in a new series that brings science to life through conversations with the world's leading minds. Join +Science on Google+: A Public Database for the latest events.Veritasium: A Science on Google+ Conversation2013-08-08 02:00:00241  
Science on Google+659,719"There's a lot of amazing science out there. Let's go discover it together."  Join Dr. +Joe Hanson  biologist and host of popular YouTube/ +PBS Digital Studios series +It's Okay To Be Smart  + +AAAS  Mass Media Fellow at +WIRED  on a journey to the awesome side of science. This hangout will be hosted by Science on Google+'s +Amy Robinson , +Jason Davison   and +Nic Hammond   . *The hangout happens on Monday, July 22rd at NOON PT/ 3 PM ET.*  Joe will answer your questions and give insights on bringing science to the masses, the power of YouTube, why GIFs are awesome and much more.  _Add your thoughts and questions for Joe on this page. Joe will invite a few insightful fans to join the hangout in person!_ Get to know Dr Joe: check out his blog at http://www.itsokaytobesmart.com/ This is the second hangout in a new series that brings science to life through conversations with the world's leading minds. Subscribe to the Science on Google+ communities for the latest.It's Okay To Be Smart: A Science on Google+ Conversation2013-07-22 21:00:00122  
Amy Robinson28,475On June 13 the U.S. Supreme Court made a landmark decision, unanimously ruling that human genes may not be patented.  What does that mean for you and me? Join geneticist +Ian Bosdet  and the +Science on Google+: A Public Database  Community for a 30 minute conversation to discuss what this ruling may mean for the future of health and genetic research. This event will be hosted by +Amy Robinson and +Nic Hammond . Ask questions for Ian to answer On Air and share your thoughts on the event page. Ian and the Science on Google+ team will invite a few insightful guests to ask their questions live in the hangout. Gene Patenting: A Google+ Science Conversation2013-07-09 21:00:0063  
ScienceSunday85,830Join hosts +Buddhini Samarasinghe and +Scott Lewis  for another “SciSunHOA”, a live Google+ Hangout On Air broadcast, brought to you by +ScienceSunday. This episode, Professor +Vincent Racaniello joins Buddhini and Scott to discuss his work in virology. Vincent is a professor of microbiology and immunology at Columbia University. His research includes the study of poliovirus (Polio), rhinovirus (Common Cold), and other RNA viruses. His work focuses on how our immune systems interact with these viruses, how they cause disease, while also discovering new viruses in wild animals. Outside of the lab, Vincent is involved in many science outreach efforts, including hosting the excellent podcast series This Week in Virology (TWiV). You can read more on his website here (http://www.virology.ws/) We’re all very excited for this episode of “SciSunHOA” as Vincent is not only a brilliant scientist, but also an outstanding science communicator! Questions for Vincent, Buddhini and Scott can be left here in the event page, as well as during the live show through the shares of the HOA, including on Twitter using the hash tag: #SciSunHOA  Going Viral: #SciSun Hangout on Air featuring Vincent Racaniello2013-04-29 00:00:0058  
Jeanne Garbarino140,475This purpose of this hangout is to help promote Brain Awareness Week (BAW), as well as breakdown neuroscience research for public consumption.  BAW is spearheaded by the Dana Foundation and the Society for Neuroscience.Be BraiNY: A conversation with neuroscientists Carol Mason and Moses Chao2013-03-06 20:00:0037  
Fraser Cain966,529Join our team of space/astronomy journalists as we bring you a quick rundown of all the breaking space news this week. Professional journalists from Universe Today, SPACE.com, Discovery, Discover Magazine, NBC, and more. We'll talk about the latest missions, biggest discoveries, and more. Hosted by Fraser Cain *Click "Yes" to "Are you going" if you want to have this event automatically put into your calendar.*Weekly Space Hangout - Oct. 11, 20122012-10-11 19:00:00252  
Kiki Sanford6,073,252What do the Democratic and Republican Presidential candidates think about science? What are their stances on science policy issues? Why should science even be a part of our modern political conversations? Join Dr. Kiki (@113166718268343560861) and @103377423155109727835, CEO of ScienceDebate.org and author of 'Fool Me Twice', for a discussion of the candidates' answers to the important questions about climate change, research, energy, space, and more posed them by ScienceDebate.org. Contact @113166718268343560861 for comments and questions prior to the event.Science Debate 2012 - The Presidential Answers2012-09-12 00:00:0027  

Shared Circles including Ian Bosdet

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Most comments: 9

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2014-10-27 19:12:53 (9 comments, 2 reshares, 18 +1s)Open 

Little known fact: Virgin births are relatively common in humans

Since we're all talking about the snake mommy who had babies without the help of a snake daddy (http://www.independent.co.uk/environment/nature/worlds-largest-snake-species-gives-virgin-birth-9818968.html), a phenomenon known as parthenogenesis, I'll link again to this study from last year looking at the incidence of this in the human population.  The authors found that self-reported virgin births in a large cohort of American females accounted for approximately 0.5% of all pregnancies.

They found statistical significant correlations between virgin births and mothers who had signed chastity pledges (P=0.007) and those whose parents indicated lower levels of communication with their children about sex and birth control (P=0.004).  Use of artificial reproductive technologies was removed as apo... more »

Most reshares: 9

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2015-04-28 22:30:00 (3 comments, 9 reshares, 32 +1s)Open 

The Government of Canada's approach to energy and the environment:

Most plusones: 32

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2015-04-28 22:30:00 (3 comments, 9 reshares, 32 +1s)Open 

The Government of Canada's approach to energy and the environment:

Latest 50 posts

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2015-08-11 16:50:05 (0 comments, 1 reshares, 11 +1s)Open 

The sun comes up and I have a chance to be kind to anyone who crosses my path because I can. I make that choice for myself and nobody has to tell me to do it. I am right with myself. I try my best to do my best, and if I fail, I try again tomorrow.

The sun comes up and I have a chance to be kind to anyone who crosses my path because I can. I make that choice for myself and nobody has to tell me to do it. I am right with myself. I try my best to do my best, and if I fail, I try again tomorrow.___

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2015-08-10 20:00:05 (0 comments, 0 reshares, 1 +1s)Open 

A wonderfully existential journey of a plastic bag, narrated by Werner Herzog. 

A wonderfully existential journey of a plastic bag, narrated by Werner Herzog. ___

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2015-08-04 19:35:45 (0 comments, 0 reshares, 0 +1s)Open 

The untenability of faitheism

Faith Versus Fact is unquestionably partisan, but its tone is matter-of-fact, and the offense that its targets will surely take will come from the force of his arguments rather than any ridicule or cheap shots.

Steven Pinker reviews +Jerry Coyne's new book Faith vs. Fact in the August issue of _Current Biology).

The untenability of faitheism

Faith Versus Fact is unquestionably partisan, but its tone is matter-of-fact, and the offense that its targets will surely take will come from the force of his arguments rather than any ridicule or cheap shots.

Steven Pinker reviews +Jerry Coyne's new book Faith vs. Fact in the August issue of _Current Biology).___

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2015-08-04 19:30:35 (3 comments, 3 reshares, 4 +1s)Open 

Quietly, without anyone really noticing, the entire Canadian blue-water navy has sunk.  It's now less-capable than those of Indonesia and Bangladesh, both of whom are long-time recipients of aid from Canada.

Quietly, without anyone really noticing, the entire Canadian blue-water navy has sunk.  It's now less-capable than those of Indonesia and Bangladesh, both of whom are long-time recipients of aid from Canada.___

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2015-06-19 03:18:19 (1 comments, 3 reshares, 15 +1s)Open 

Probably getting close though...

Probably getting close though...___

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2015-06-18 20:16:03 (2 comments, 1 reshares, 8 +1s)Open 

At press time, residents of the only economically advanced nation in the world where roughly two mass shootings have occurred every month for the past five years were referring to themselves and their situation as “helpless .”

At press time, residents of the only economically advanced nation in the world where roughly two mass shootings have occurred every month for the past five years were referring to themselves and their situation as “helpless .”___

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2015-06-01 17:53:09 (2 comments, 0 reshares, 2 +1s)Open 

The 2015 World Cup has just begun

At press time, the U.S. national team was leading defending champions Germany in the World Cup’s opening match after being awarded 12 penalties in the game’s first three minutes.

The 2015 World Cup has just begun

At press time, the U.S. national team was leading defending champions Germany in the World Cup’s opening match after being awarded 12 penalties in the game’s first three minutes.___

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2015-06-01 03:52:36 (2 comments, 0 reshares, 3 +1s)Open 

Nothing On

Nothing On___

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2015-05-29 16:49:29 (2 comments, 0 reshares, 1 +1s)Open 

What this reporter failed to note is that this is a copy of policies developed by the Canadian Government (although it sounds less restrictive).

If someone asks you a question, any question, or you have the urge to say something, anything, then you must first fill in the form.  Once the form has been approved and signed off by your line manager, the communications committee and the Principal, you can say the words.

What this reporter failed to note is that this is a copy of policies developed by the Canadian Government (although it sounds less restrictive).

If someone asks you a question, any question, or you have the urge to say something, anything, then you must first fill in the form.  Once the form has been approved and signed off by your line manager, the communications committee and the Principal, you can say the words.___

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2015-05-28 18:03:28 (1 comments, 0 reshares, 3 +1s)Open 

Wow - Google Photos will now give you unlimited space for photos up to 16MP in size (and 1080p videos).  Certainly giving Flickr's 1TB of space some competition.

Wow - Google Photos will now give you unlimited space for photos up to 16MP in size (and 1080p videos).  Certainly giving Flickr's 1TB of space some competition.___

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2015-05-27 20:26:27 (3 comments, 3 reshares, 8 +1s)Open 

Selecting a Medical Specialty

Based on some acquaintances I think this is actually how it works.

Selecting a Medical Specialty

Based on some acquaintances I think this is actually how it works.___

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2015-05-25 20:52:27 (2 comments, 0 reshares, 8 +1s)Open 

Right-To-Try laws: bad for patients

Right to try laws are being passed in many US states.  On the surface, these laws allow terminally-ill patients to access experimental drugs that may help them.  Hard to argue against that and not seem like a horrible person, but in the linked article below Orac outlines why these are more likely to cause harm to patients.  He, quite sensibly as usual, argues for support of the FDA's Compassionate Access program.  If you don't want to read the whole thing (you should) then here's what he's getting at:

The key difference between right-to-try and FDA compassionate use programs is that right-to-try strips pretty much all protections from patients who would use it; requires them to pay for the drug and any care related to the drug; prevents them from suing manufacturers and doctors if something goes wrong; prevents the statefro... more »

Right-To-Try laws: bad for patients

Right to try laws are being passed in many US states.  On the surface, these laws allow terminally-ill patients to access experimental drugs that may help them.  Hard to argue against that and not seem like a horrible person, but in the linked article below Orac outlines why these are more likely to cause harm to patients.  He, quite sensibly as usual, argues for support of the FDA's Compassionate Access program.  If you don't want to read the whole thing (you should) then here's what he's getting at:

The key difference between right-to-try and FDA compassionate use programs is that right-to-try strips pretty much all protections from patients who would use it; requires them to pay for the drug and any care related to the drug; prevents them from suing manufacturers and doctors if something goes wrong; prevents the state from taking action against the licenses of providers who give patients bad advice recommending right-to-try; tells insurance companies that, not only do they not have to pay for the investigational agent or device, but they don’t have to pay for any complications arising from use of the investigational agent or device; and makes doctors and other health care providers working for right-to-try states leery of advising too strongly against right-to-try, lest they be prosecuted for “blocking” access to experimental drugs. FDA compassionate use programs, in marked contrast, require review and oversight by an institutional review board (IRB). The other difference was that, although 99.5% of compassionate use/expanded access requests are approved by the FDA, the process was onerous. As Dr. Peppercorn points out, that is rapidly changing, arguably eliminating the “need” for right-to-try.___

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2015-05-25 20:50:28 (4 comments, 5 reshares, 7 +1s)Open 

Right-To-Try laws: bad for patients

Right to try laws are being passed in many US states.  On the surface, these laws allow terminally-ill patients to access experimental drugs that may help them.  Hard to argue against that and not seem like a horrible person, but in the linked article below Orac outlines why these are more likely to cause harm to patients.  He, quite sensibly as usual, argues for support of the FDA's Compassionate Access program.  If you don't want to read the whole thing (you should) then here's what he's getting at:

The key difference between right-to-try and FDA compassionate use programs is that right-to-try strips pretty much all protections from patients who would use it; requires them to pay for the drug and any care related to the drug; prevents them from suing manufacturers and doctors if something goes wrong; prevents the statefro... more »

Right-To-Try laws: bad for patients

Right to try laws are being passed in many US states.  On the surface, these laws allow terminally-ill patients to access experimental drugs that may help them.  Hard to argue against that and not seem like a horrible person, but in the linked article below Orac outlines why these are more likely to cause harm to patients.  He, quite sensibly as usual, argues for support of the FDA's Compassionate Access program.  If you don't want to read the whole thing (you should) then here's what he's getting at:

The key difference between right-to-try and FDA compassionate use programs is that right-to-try strips pretty much all protections from patients who would use it; requires them to pay for the drug and any care related to the drug; prevents them from suing manufacturers and doctors if something goes wrong; prevents the state from taking action against the licenses of providers who give patients bad advice recommending right-to-try; tells insurance companies that, not only do they not have to pay for the investigational agent or device, but they don’t have to pay for any complications arising from use of the investigational agent or device; and makes doctors and other health care providers working for right-to-try states leery of advising too strongly against right-to-try, lest they be prosecuted for “blocking” access to experimental drugs. FDA compassionate use programs, in marked contrast, require review and oversight by an institutional review board (IRB). The other difference was that, although 99.5% of compassionate use/expanded access requests are approved by the FDA, the process was onerous. As Dr. Peppercorn points out, that is rapidly changing, arguably eliminating the “need” for right-to-try.___

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2015-05-15 17:41:22 (0 comments, 0 reshares, 0 +1s)Open 

Sad news about BB.  I hope Lucille is well taken care of.

Sad news about BB.  I hope Lucille is well taken care of.___

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2015-05-15 00:11:21 (2 comments, 2 reshares, 1 +1s)Open 

At 35, you have 20‑30 per cent chance of your frozen eggs creating a baby in the future, using IVF. At 42, it is 3.9 per cent

At 35, you have 20‑30 per cent chance of your frozen eggs creating a baby in the future, using IVF. At 42, it is 3.9 per cent___

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2015-05-13 17:09:58 (2 comments, 0 reshares, 7 +1s)Open 

Thing Explainer

So awesome.  Randall Munroe is releasing a new book called Thing Explainer.  I have his previous book What If and it is a fantastic read.  Too bad we have to wait until November to see this one.

"In Thing Explainer: Complicated Stuff in Simple Words, things are explained in the style of Up Goer Five, using only drawings and a vocabulary of the 1,000 (or "ten hundred") most common words. Explore computer buildings (datacenters), the flat rocks we live on (tectonic plates), the things you use to steer a plane (airliner cockpit controls), and the little bags of water you're made of (cells)."

Thing Explainer

So awesome.  Randall Munroe is releasing a new book called Thing Explainer.  I have his previous book What If and it is a fantastic read.  Too bad we have to wait until November to see this one.

"In Thing Explainer: Complicated Stuff in Simple Words, things are explained in the style of Up Goer Five, using only drawings and a vocabulary of the 1,000 (or "ten hundred") most common words. Explore computer buildings (datacenters), the flat rocks we live on (tectonic plates), the things you use to steer a plane (airliner cockpit controls), and the little bags of water you're made of (cells)."___

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2015-05-13 16:47:41 (2 comments, 3 reshares, 6 +1s)Open 

As always, Randall has a unique view on the world.

https://xkcd.com/1524/ 

As always, Randall has a unique view on the world.

https://xkcd.com/1524/ ___

2015-05-12 23:24:31 (2 comments, 0 reshares, 3 +1s)Open 

That's a LOT of authors

This paper in Genes, Genomes, Genetics has what appears to be over 1,000 authors (1,021 is my estimate but I cheated and used a BASH script to count the commas in the author list - feel free to check my work).  I wonder if that makes the author list more information-dense than the tiny Drosophila chromosome they were studying. 

http://www.g3journal.org/content/5/5/719.full

That's a LOT of authors

This paper in Genes, Genomes, Genetics has what appears to be over 1,000 authors (1,021 is my estimate but I cheated and used a BASH script to count the commas in the author list - feel free to check my work).  I wonder if that makes the author list more information-dense than the tiny Drosophila chromosome they were studying. 

http://www.g3journal.org/content/5/5/719.full___

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2015-05-12 23:22:06 (0 comments, 0 reshares, 8 +1s)Open 

From Canada, Baby Charlotte gets a snowsuit (of course) and her name on a $100,000 donation to a pro-vaccination advocacy group.  Nice.

From Canada, Baby Charlotte gets a snowsuit (of course) and her name on a $100,000 donation to a pro-vaccination advocacy group.  Nice.___

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2015-05-12 17:07:45 (2 comments, 4 reshares, 23 +1s)Open 

I've never been interested in drones before but this thing looks pretty cool.

I've never been interested in drones before but this thing looks pretty cool.___

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2015-05-11 02:25:56 (1 comments, 0 reshares, 4 +1s)Open 

Vancouver. Saturday. 

Vancouver. Saturday. ___

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2015-05-10 14:35:08 (2 comments, 2 reshares, 7 +1s)Open 

Happy Mother's Day.  Use the handy chart below to figure out how you're related to all the distant family members that Mom talks about today.

Happy Mother's Day.  Use the handy chart below to figure out how you're related to all the distant family members that Mom talks about today.___

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2015-05-09 04:55:45 (6 comments, 8 reshares, 12 +1s)Open 

___

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2015-05-08 20:36:46 (0 comments, 0 reshares, 4 +1s)Open 

CCMG releases position statement on genome-wide sequencing

The Canadian College of Medical Geneticists (of which I am a member) has today released a position statement on the use of whole-genome sequencing for clinical genetic diagnostics.  I think it does a really good job of exploring the practical, ethical and scientific complexities of this technology.  

One of (I am going to guess) the more controversial recommendations is that labs should limit their analyses to genes clearly associated with the patient's disease phenotype.  What this means is that if you're investigating someone for, say, cardiomyopathy, then the bioinformatic analysis should avoid genes such as the hereditary cancer genes like BRCA1 or TP53.  This will have the effect of minimizing incidental findings for unrelated disorders i.e. "we didn't figure our your heart condition but I havebad... more »

CCMG releases position statement on genome-wide sequencing

The Canadian College of Medical Geneticists (of which I am a member) has today released a position statement on the use of whole-genome sequencing for clinical genetic diagnostics.  I think it does a really good job of exploring the practical, ethical and scientific complexities of this technology.  

One of (I am going to guess) the more controversial recommendations is that labs should limit their analyses to genes clearly associated with the patient's disease phenotype.  What this means is that if you're investigating someone for, say, cardiomyopathy, then the bioinformatic analysis should avoid genes such as the hereditary cancer genes like BRCA1 or TP53.  This will have the effect of minimizing incidental findings for unrelated disorders i.e. "we didn't figure our your heart condition but I have bad news for you and your family about colon cancer".  One could also argue that it's instead a missed chance at opportunistic screening, which is the side that US labs and the ACMG seem to have landed on.

It's a complex topic and it will continue to evolve along with the technology and our knowledge of the genetics of disease.  For now, these recommendations feel like a sensible approach and it's nice to have some additional guidance and consensus in the community.

Paper linked below.  It's peer-reviewed and Open Access. ___

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2015-05-08 20:21:14 (2 comments, 0 reshares, 1 +1s)Open 

#26. a generic item of clothing

#26. a generic item of clothing___

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2015-05-07 20:29:06 (0 comments, 1 reshares, 1 +1s)Open 

CCMG releases position statement on genome-wide sequencing

The Canadian College of Medical Geneticists (of which I am a member) has today released a position statement on the use of whole-genome sequencing for clinical genetic diagnostics.  I think it does a really good job of exploring the practical, ethical and scientific complexities of this technology.  

One of (I am going to guess) the more controversial recommendations is that labs should limit their analyses to genes clearly associated with the patient's disease phenotype.  What this means is that if you're investigating someone for, say, cardiomyopathy, then the bioinformatic analysis should avoid genes such as the hereditary cancer genes like BRCA1 or TP53.  This will have the effect of minimizing incidental findings for unrelated disorders i.e. "we didn't figure our your heart condition but I havebad... more »

CCMG releases position statement on genome-wide sequencing

The Canadian College of Medical Geneticists (of which I am a member) has today released a position statement on the use of whole-genome sequencing for clinical genetic diagnostics.  I think it does a really good job of exploring the practical, ethical and scientific complexities of this technology.  

One of (I am going to guess) the more controversial recommendations is that labs should limit their analyses to genes clearly associated with the patient's disease phenotype.  What this means is that if you're investigating someone for, say, cardiomyopathy, then the bioinformatic analysis should avoid genes such as the hereditary cancer genes like BRCA1 or TP53.  This will have the effect of minimizing incidental findings for unrelated disorders i.e. "we didn't figure our your heart condition but I have bad news for you and your family about colon cancer".  One could also argue that it's instead a missed chance at opportunistic screening, which is the side that US labs and the ACMG seem to have landed on.

It's a complex topic and it will continue to evolve along with the technology and our knowledge of the genetics of disease.  For now, these recommendations feel like a sensible approach and it's nice to have some additional guidance and consensus in the community.

Paper linked below.  It's peer-reviewed and Open Access. ___

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2015-05-05 21:57:17 (0 comments, 6 reshares, 4 +1s)Open 

Nature has a Statistics for Biologists portal.  Lots of good primers on the use (and misuse) of statistics in here, including their fantastic Points of Significance series.

Nature has a Statistics for Biologists portal.  Lots of good primers on the use (and misuse) of statistics in here, including their fantastic Points of Significance series.___

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2015-05-05 17:26:12 (1 comments, 0 reshares, 4 +1s)Open 

Funders to insist that all scientific groups contain at least two men

"We can’t be allowing groups to contain too many women, that’d be weird"

Funders to insist that all scientific groups contain at least two men

"We can’t be allowing groups to contain too many women, that’d be weird"___

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2015-05-02 16:28:53 (3 comments, 0 reshares, 7 +1s)Open 

___

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2015-05-01 23:25:31 (0 comments, 0 reshares, 1 +1s)Open 

#Leo more likely to have GI hemorrhage, #Sagittarius a humerus fracture. The dangers of multiple hypothesis testing revealed (yet again).

#Leo more likely to have GI hemorrhage, #Sagittarius a humerus fracture. The dangers of multiple hypothesis testing revealed (yet again).___

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2015-04-28 22:30:00 (3 comments, 9 reshares, 32 +1s)Open 

The Government of Canada's approach to energy and the environment:

The Government of Canada's approach to energy and the environment:___

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2015-04-27 00:46:05 (0 comments, 0 reshares, 5 +1s)Open 

Daffodils and Dementia

✿ It's spring time in Maryland, and in the words of the poet Wordsworth, my heart dances with the daffodils. Through the long winter, I conjured up memories of these cheerful blooms in my mind:

For oft, when on my couch I lie
In vacant or in pensive mood,
They flash upon that inward eye
Which is the bliss of solitude;
And then my heart with pleasure fills,
And dances with the daffodils.

✿ But an estimated 44 million people world wide who suffer from Alzheimer's disease are robbed of their memories by a progressive dementia. As the 6th leading cause of death in the U.S., Alzheimer's cannot be cured or prevented. One of the handful of drugs available to improve memory loss in patients is galantamine, which is extracted from the leaves and bulbs of daffodils (Narcissus) and snowdrops(Ga... more »

Daffodils and Dementia

✿ It's spring time in Maryland, and in the words of the poet Wordsworth, my heart dances with the daffodils. Through the long winter, I conjured up memories of these cheerful blooms in my mind:

For oft, when on my couch I lie
In vacant or in pensive mood,
They flash upon that inward eye
Which is the bliss of solitude;
And then my heart with pleasure fills,
And dances with the daffodils.

✿ But an estimated 44 million people world wide who suffer from Alzheimer's disease are robbed of their memories by a progressive dementia. As the 6th leading cause of death in the U.S., Alzheimer's cannot be cured or prevented. One of the handful of drugs available to improve memory loss in patients is galantamine, which is extracted from the leaves and bulbs of daffodils (Narcissus) and snowdrops (Galanthus). These extracts have been in use since ancient times. In Homer's Greek epic, Odysseus is said to have used snowdrops to clear his mind bewitched by Circe. In the 1950s, a pharmacologist observed inhabitants of a remote Bulgarian village rubbing the extracts on their forehead and shortly after, the drug was approved for medical use. Galantamine increases the action of the neurotransmitter acetylcholine in some parts of the brain, both by making the receptor more sensitive to its action and by slowing down its removal. The drug has other interesting properties: it is said to promote lucid dreaming, improve sleep quality, memory loss in brain damage, and some autistic symptoms (http://en.wikipedia.org/wiki/Galantamine).  

✿ No drug has yet stopped the inexorable progress of Alzheimer's. Early intervention is key to effective treatment: in my lab, for example, we are studying endosomal pathology which is the earliest sign of problems at the cellular level (http://goo.gl/DtVUFT). Yet lack of funding stifles productive research. As Newt Gingrich points out in his recent Op-Ed for New York Times, we spend only 0.8% of the estimated 154 billion dollars of annual medical costs related to Alzheimer's disease on research to cure or prevent it

News Story: Newt Gingrich: Double the NIH Budget. April 22, 2015 http://goo.gl/Fq4PAS 

Daffodil GIF: http://headlikeanorange.tumblr.com/

#ScienceSunday  ___

2015-04-23 23:10:49 (0 comments, 0 reshares, 1 +1s)Open 

"Most reclassified #VUS (#ACMG 3 variants) are downgraded to benign"  
Anyone know of reference/data to support/refute this statement?

"Most reclassified #VUS (#ACMG 3 variants) are downgraded to benign"  
Anyone know of reference/data to support/refute this statement?___

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2015-04-20 22:30:11 (6 comments, 6 reshares, 19 +1s)Open 

"Scientists now agree—overwhelmingly—that the remedies don't work. But each year, billions of dollars worth of homeopathic products are sold in the U.S."

"Scientists now agree—overwhelmingly—that the remedies don't work. But each year, billions of dollars worth of homeopathic products are sold in the U.S."___

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2015-04-18 05:59:23 (3 comments, 5 reshares, 9 +1s)Open 

"Seclusion makes gluten healthier." Totally true. Go ahead and eat that muffin if nobody is watching!

Happy Birthday +diana chard :)

"Seclusion makes gluten healthier." Totally true. Go ahead and eat that muffin if nobody is watching!

Happy Birthday +diana chard :)___

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2015-04-17 19:54:10 (0 comments, 2 reshares, 7 +1s)Open 

These are so sad.

#iwishmyteacherknew I don't have a friend to play with me

These are so sad.

#iwishmyteacherknew I don't have a friend to play with me___

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2015-04-16 22:42:11 (5 comments, 1 reshares, 16 +1s)Open 

Dr. Oz is guilty of either outrageous conflicts of interest or flawed judgements about what constitutes appropriate medical treatments, or both. Whatever the nature of his pathology, members of the public are being misled and endangered, which makes Dr. Oz's presence on the faculty of a prestigious medical institution unacceptable.

Dr. Oz is guilty of either outrageous conflicts of interest or flawed judgements about what constitutes appropriate medical treatments, or both. Whatever the nature of his pathology, members of the public are being misled and endangered, which makes Dr. Oz's presence on the faculty of a prestigious medical institution unacceptable.___

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2015-04-15 16:47:52 (1 comments, 3 reshares, 5 +1s)Open 

Are you worried that sometimes you're too anxious?  

Are you worried that sometimes you're too anxious?  ___

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2015-04-15 16:28:45 (7 comments, 1 reshares, 11 +1s)Open 

“I knew I was right! All the research I did online paid off. No need for expensive invasive surgery with time honored treatments.”

“I knew I was right! All the research I did online paid off. No need for expensive invasive surgery with time honored treatments.”___

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2015-04-13 23:14:16 (1 comments, 0 reshares, 1 +1s)Open 

Seven Actionable Strategies for Advancing Women in Science, Engineering, and Medicine

From the March issue of Cell Stem Cell, a report on the inaugural meeting of NYSCF’s Initiative on Women in Science and Engineering (IWISE).  

"It is the IWISE Working Group’s hope that eventually we will stop talking about women in science and start talking about equality in science, so that in time, excellence, not gender or any other measure of diversity, is the only standard that must be considered."

Here are their seven proposed strategies:

1. Implement Flexible Family Care Spending
2. Provide “Extra Hands” Award
3. Recruit Gender-Balanced External Review Committees and Speaker Selection Committees
4. Incorporate Implicit Bias Statements
5. Focus on Education as a Tool
6. Create an Institutional Report Card forGender Eq... more »

Seven Actionable Strategies for Advancing Women in Science, Engineering, and Medicine

From the March issue of Cell Stem Cell, a report on the inaugural meeting of NYSCF’s Initiative on Women in Science and Engineering (IWISE).  

"It is the IWISE Working Group’s hope that eventually we will stop talking about women in science and start talking about equality in science, so that in time, excellence, not gender or any other measure of diversity, is the only standard that must be considered."

Here are their seven proposed strategies:

1. Implement Flexible Family Care Spending
2. Provide “Extra Hands” Award
3. Recruit Gender-Balanced External Review Committees and Speaker Selection Committees
4. Incorporate Implicit Bias Statements
5. Focus on Education as a Tool
6. Create an Institutional Report Card for Gender Equality (below)
7. Partner to Expand upon Existing Searchable Databases of Women in Science, Medicine, and Engineering___

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2015-04-13 19:27:01 (3 comments, 0 reshares, 11 +1s)Open 

Hi again.  2014 was a bit of a year for me.  We all have them every now and then, and I guess my turn came up.  One of the consequences of this is that I was largely absent from G+ for most of the year.  I continued to run across little tidbits that I thought would make great posts, but I never really found the time or energy to put many together.   But I think I’ve finally recovered enough to dive back in.  A quick browse through my stream today reminds me of what I’ve been missing and makes me wish I could rewind it for a year and catch up.

Hi again.  2014 was a bit of a year for me.  We all have them every now and then, and I guess my turn came up.  One of the consequences of this is that I was largely absent from G+ for most of the year.  I continued to run across little tidbits that I thought would make great posts, but I never really found the time or energy to put many together.   But I think I’ve finally recovered enough to dive back in.  A quick browse through my stream today reminds me of what I’ve been missing and makes me wish I could rewind it for a year and catch up.___

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2014-12-10 19:03:48 (0 comments, 0 reshares, 1 +1s)Open 

This analysis looks at the validity of whole genome sequencing in a clinical setting. As this technique becomes more affordable and practical, how can we use it in this setting?

#genomesequencing   #genome  

This analysis looks at the validity of whole genome sequencing in a clinical setting. As this technique becomes more affordable and practical, how can we use it in this setting?

#genomesequencing   #genome  ___

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2014-11-22 16:07:51 (1 comments, 4 reshares, 16 +1s)Open 

It is a rough road that leads to the heights of greatness.

It is a rough road that leads to the heights of greatness.___

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2014-11-12 19:53:02 (0 comments, 0 reshares, 0 +1s)Open 

In a result that has shocked the entire field, researchers led by Dr Callum Porker at the University of Aberdeen have revealed that some microbiome studies are becoming contaminated with real science. ... The paper, published today in BMC Couldn’t Get In To Genome Biology, has caused quite a stir

In a result that has shocked the entire field, researchers led by Dr Callum Porker at the University of Aberdeen have revealed that some microbiome studies are becoming contaminated with real science. ... The paper, published today in BMC Couldn’t Get In To Genome Biology, has caused quite a stir___

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2014-11-03 18:13:05 (6 comments, 2 reshares, 16 +1s)Open 

The Oatmeal tells us what we probably already know: printer manufacturers hate us all and want us to be miserable.  And they're succeeding. 

Longer version here: http://theoatmeal.com/comics/printers___The Oatmeal tells us what we probably already know: printer manufacturers hate us all and want us to be miserable.  And they're succeeding. 

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2014-11-02 16:27:28 (3 comments, 6 reshares, 10 +1s)Open 

Shit My Reviewers Say

This is brilliant.  Real comments from "peer" reviews.

Shit My Reviewers Say

This is brilliant.  Real comments from "peer" reviews.___

2014-11-02 00:59:57 (0 comments, 0 reshares, 3 +1s)Open 

The metronome is the least-effective of all study aids.  Beer, the second.

The metronome is the least-effective of all study aids.  Beer, the second.___

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2014-11-01 03:58:12 (5 comments, 0 reshares, 21 +1s)Open 

Yoda pumpkin

This took a while...

Yoda pumpkin

This took a while...___

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2014-10-27 19:12:53 (9 comments, 2 reshares, 18 +1s)Open 

Little known fact: Virgin births are relatively common in humans

Since we're all talking about the snake mommy who had babies without the help of a snake daddy (http://www.independent.co.uk/environment/nature/worlds-largest-snake-species-gives-virgin-birth-9818968.html), a phenomenon known as parthenogenesis, I'll link again to this study from last year looking at the incidence of this in the human population.  The authors found that self-reported virgin births in a large cohort of American females accounted for approximately 0.5% of all pregnancies.

They found statistical significant correlations between virgin births and mothers who had signed chastity pledges (P=0.007) and those whose parents indicated lower levels of communication with their children about sex and birth control (P=0.004).  Use of artificial reproductive technologies was removed as apo... more »

Little known fact: Virgin births are relatively common in humans

Since we're all talking about the snake mommy who had babies without the help of a snake daddy (http://www.independent.co.uk/environment/nature/worlds-largest-snake-species-gives-virgin-birth-9818968.html), a phenomenon known as parthenogenesis, I'll link again to this study from last year looking at the incidence of this in the human population.  The authors found that self-reported virgin births in a large cohort of American females accounted for approximately 0.5% of all pregnancies.

They found statistical significant correlations between virgin births and mothers who had signed chastity pledges (P=0.007) and those whose parents indicated lower levels of communication with their children about sex and birth control (P=0.004).  Use of artificial reproductive technologies was removed as a possible source of the virgin births, although the authors could not exclude divine intervention.

Here's a link to the full study: http://www.bmj.com/content/347/bmj.f7102 ___

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2014-10-26 21:13:15 (1 comments, 1 reshares, 4 +1s)Open 

Filtering the baby with the bathwater

This group from Dana-Faber found that the gene RNF43 is frequently mutated in colorectal and endometrial cancers.  Almost 20% of them, and more than half of a particular subtype.  It's an important result but one might ask, with all the tumour sequencing that has gone on in the last few years why did nobody find these mutations before?

Turns out that the mutations are commonly in gene regions (GC dinucleotide repeats) that commonly sequence poorly with today's instruments.  If the gene has six GC repeats the data will often show six repeats, but also some of the data will be seven repeats and some will be five:

GCGCGCGCGCGC
GCGCGCGCGCGCGC
GCGCGCGCGCGC
GCGCGCGCGCGCGC
GCGCGCGCGC
GCGCGCGCGCGC

This results in noisy data for that particular gene region, and there are many such regions inth... more »

Filtering the baby with the bathwater

This group from Dana-Faber found that the gene RNF43 is frequently mutated in colorectal and endometrial cancers.  Almost 20% of them, and more than half of a particular subtype.  It's an important result but one might ask, with all the tumour sequencing that has gone on in the last few years why did nobody find these mutations before?

Turns out that the mutations are commonly in gene regions (GC dinucleotide repeats) that commonly sequence poorly with today's instruments.  If the gene has six GC repeats the data will often show six repeats, but also some of the data will be seven repeats and some will be five:

GCGCGCGCGCGC
GCGCGCGCGCGCGC
GCGCGCGCGCGC
GCGCGCGCGCGCGC
GCGCGCGCGC
GCGCGCGCGCGC

This results in noisy data for that particular gene region, and there are many such regions in the genome.  So today's bioinformatic softwares will normally filter (remove) such regions assuming that they are technical artefacts.  However, whenever you filter the data to remove noise you risk tossing out real biological data too, something I try to emphasize whenever I teach students and residents (and physicians) about sequencing and sequence data analysis.___

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