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Ian Bosdet has been at 19 events

HostFollowersTitleDateGuestsLinks
Science on Google+391,137Please join us for Developmental Science HOA, a new collaborative Hangout On Air series which is co-hosted by +Science on Google+ and +Developmental Psychology. In the first Developmental Science HOA we will be talking with Dr. +Gedeon Deák. +Gedeon Deák is a Professor of Cognitive Science and Human Development at +University of California, San Diego and is the director of the +Cognitive Development Laboratory at UC-San Diego. +Gedeon Deák studies the dynamics of infant social interactions and social learning, using experimental behavioral paradigms, ethnographic investigations, physiological studies, and computer simulations. He and his collaborators conducted the first study of real-time interactions between parents and toddlers with high-density EEG and motion capture of both participants. He also studies how children learn and use words, and how they flexibly shift their attention, representations, and inferences.Important LinksCurriculum Vitae: http://goo.gl/qLtUaCLab Website: http://goo.gl/AQ78h6ResearchGate: http://goo.gl/Mj8deHRelevant PapersWatch the hands: infants can learn to follow gaze by seeing adults manipulate objects: http://goo.gl/bSMzKyYoung children’s fast mapping and generalization of words, facts, and pictograms :http://goo.gl/nhykZFA Unified Account of Gaze Following: http://goo.Developmental Science HOA: Episode 12014-08-05 18:00:0097G+
STEM Women on G+98,971Join us for a STEM Women HOA as we speak to Professor +Julia Greer  on her career as a materials scientist. Julia works on 3D nanomaterials, and her research specialises in the creation of extremely strong yet ultra-light materials. She will talk to us about her fascinating career path and diverse interests, along with ways in which academia can be more supportive of STEM parents. This HOA will be hosted by Dr +Buddhini Samarasinghe  and Dr +Zuleyka Zevallos    and you can tune in on Sunday June 22nd at 2.30 PM Pacificl/ 10.30PM UK. The hangout will be available for viewing on our YouTube channel (http://www.youtube.com/stemwomen) after the event.In the Spotlight, with Professor Julia Greer2014-06-22 23:30:0033G+
Joanne Manaster87,553Join +Jeff Shaumeyer  and +Joanne Manaster for this episode of +Read Science! where their guest +Chad Orzel tells us all about teaching the general public a bit of physics here and there. Oh, and all dogs are welcome!  Thursday, June 19, 2014 at 12:30pm EDT, 11:30 CDT --About one hour longRead Science! "My Dog Knows Physics" Episode2014-06-19 19:30:0035G+
Pamela L. Gay86,867Join us to talk with Moon pioneers +Penn State Lunar Lion XPRIZE Team and +Earthrise Space Foundation  and find out how they're engaging students -- and heading to the Moon!OverviewA global team of scientists and engineers are all working toward constructing missions to land on, travel across, and send video back from the Moon. With this new Google Hangout on Air series, we will introduce you to the men and women behind each of these planned missions and bring you all the latest developments from the +Google Lunar XPRIZE .Google Lunar XPRIZE Team Hangout 005: Rockets and Students ENGAGE!2014-05-28 03:00:4824G+
STEM Women on G+98,971Join us for a STEM Women HOA as we speak to  +Erin Kane on her career as a primatologist. Erin is a graduate student in physical anthropology who recently returned to Ohio after an extended field trip. She will talk to us about her recent experiences in the field working with Diana monkeys, her exciting career path as a woman in STEM, what inspires her, and why supporting women in STEM is important. This HOA will be hosted by Dr +Buddhini Samarasinghe  and Dr +Zuleyka Zevallos   and you can tune in on Sunday May 25th at 4.30 PM Central/ 10.30PM UK. The hangout will be available for viewing on our YouTube channel (http://www.youtube.com/stemwomen) after the event.In The Spotlight, With Erin Kane2014-05-25 23:30:0051G+
Science on Google+391,137Join us for a Science on Google+ HOA as we speak to +Akinola Emmanuel and Dr +shilpa keerthivasan about their recently published research on cancer signalling (http://stm.sciencemag.org/content/6/225/225ra28). We will discuss the basics of cancer signalling, explain the link between inflammation and cancer, and how their research identifies a novel role for immune cells in the development of colon cancer. This Pub Talks HOA will be part of a series in which we explain published research in a jargon-free manner that is understandable to the public.This HOA will be hosted by Dr +Buddhini Samarasinghe and you can tune in on Sunday March 23rd at 2 PM CDT/ 12PM PDT/ 7 PM GMT. The hangout will be available for viewing on our YouTube channel (https://www.youtube.com/ScienceHangouts) after the event.Pub Talks: Cancer Signalling2014-03-23 20:00:0086G+
STEM Women on G+98,971Join us for a STEM Women HOA as we speak to Dr.  +Yonatan Zunger on how men can help with the issues of gender inequality in STEM fields. Yonatan is the Chief Architect of Google+ and also has a PhD in Physics with a strong engineering background. He is a passionate advocate of gender equality in STEM, and will talk to us about what we can do to encourage women in STEM.This HOA will be hosted by Dr +Buddhini Samarasinghe   and Dr +Zuleyka Zevallos  , and you can tune in on Sunday March 2nd at 12.30 PM Pacific/ 8.30PM GMT. The hangout will be available for viewing on our YouTube channel(http://www.youtube.com/stemwomen) after the event.Follow us on Twitter @stemwomen and on www.stemwomen.netSTEM Women: How Men Can Help with Dr Yonatan Zunger2014-03-02 21:30:0097G+
Science on Google+391,137Can you believe it! The +Science on Google+ community is approaching 200k members! We'll have reached that number by this weekend, so we're going to have a huge community celebration!Join your hosts +Scott Lewis and +Buddhini Samarasinghe as they start the celebration of being the #1 science community and the #10 community in all of Google+!! During our Hangout On Air, you'll get a chance to meet the moderators  who dedicate so much time and energy into making sure that good, high quality science content is showcased in the community. After we hear from the moderators on who they are, we'll have a discussion on what the curator team looks at for community posts to get put on the Curator's Choice. We are all extremely excited to be celebrating with all 200,000 of you! Let's stay curious and find new and better ways to understand this amazing Universe we all live in!#ScienceSunday   #STEM   #ScienceEveryday   #SoGp200k  200,000 member community celebration!2014-01-12 22:00:00184G+
Science on Google+391,137Isaac Newton's Birthday is on ChristmasJoin us in a Newton-inspired holiday physics hangout with rockstar physicist +Henry Reich of +MinutePhysics and +MinuteEarth  and brilliant ballerina biologist +Carin Bondar of +National Geographic, +Scientific American and host of Wild Sex, a science show about the strange reproductive habits of the animal kingdom. She knows how the world gets physical. +Veritasium  AKA +Derek Muller may pop in.  We hear there may even be more special guests so you should probably go ahead and RSVP yes to join the lively conversation. BYOB. Hosted by +Amy Robinson of +Science on Google+ .Happy Newtonmas Hangout2013-12-19 00:00:00145G+
Science on Google+391,137Join mathematicians Dana Ernst , Sara Del Valle , Vincent Knight , Luis Guzman  and Robert Jacobson  as they talk with Amy Robinson  about their favorite math gifs and ideas and what it's like to be a mathematician. How many numbers are there? Do mathematicians see the world differently? And why is the last panel of this xkcd comic funny? http://xkcd.com/804/+Dana Ernst   is an assistant professor in the Department of Mathematics and Statistics at Northern Arizona University in Flagstaff, AZ, USA. +Sara Del Valle   is a mathematical epidemiologist at Los Alamos National Laboratory in Los Alamos, NM, USA.+Vincent Knight   is a LANCS lecturer at the Cardiff University School of Mathematics in Operational Research in Cardiff, Wales, UK.+Luis Guzman   is a graduate student in mathematics at the University of West Florida in FL, USA.+Robert Jacobson   is Assistant Professor of Mathematics at Roger Williams University in RI, USA.Hangout hosted by Science on Google+'s +Amy Robinson Math: from GIFs to xkcd2013-11-22 02:00:0064G+
Imagine Science Films426,433On September 25 at 11AM (EST), #Experimenta invites the legendary +Carl Zimmer  for a discussion about the marriage between science and moving images and his Jury Emeritus status at Imagine Science Films. Join us for a dissection into the raw matter that makes up scientific movie-making.Into The Dark Matter of Scientific Movie-Making With Carl Zimmer2013-09-25 17:00:0038G+
Science on Google+391,137Posterside Hangouts is a new Hangouts On Air, which is hosted by the Science on Google+ Community (http://goo.gl/uhJCN). The main goal of this HOA series is to recreate a poster session-like atmosphere here on G+, so researchers can present their recent findings. Presentations will be grouped by discipline and individual presentations will last approximately 10 – 15 minutes.Do you have a recent conference presentation, manuscript, or book that you would like to share with the Google+ community? Do you want to give your undergraduate or graduate students practice presenting their research? If yes, then let us know by filling out this short form: http://goo.gl/e0KPhE.================================Psychology Talks for Posterside Hangouts #1, Authors (Affiliations)When audition dominates vision: Evidence from cross-modal statistical learning+Chris Robinson (The Ohio State University at Newark)Automatic selection of eye tracking variables in visual categorization for adults and infants+Samuel Rivera (The Ohio State University at Columbus)Foreign accent does not influence cognitive judgments+Andre L. Souza (Concordia University) and +Art Markman (The University of Texas at Austin)Positive mood may enhance cognitive flexibility: Evidence from category learning+Paul Minda (The University of Western Ontario) and +Ruby Nadler(The University of Western Ontario)The effects of aging on face perception+Allison Sekuler (McMaster University)================================Abstracts and LinksWhen audition dominates vision: Evidence from cross-modal statistical learningPresenting information to multiple sensory modalities sometimes facilitates and sometimes interferes with processing of this information. Research examining interference effects shows that auditory input often interferes with processing of visual input in young children (i.e., auditory dominance effect), whereas visual input often interferes with auditory processing in adults (i.e., visual dominance effect). The current study used a cross-modal statistical learning task to examine modality dominance in adults. Participants ably learned auditory and visual statistics when auditory and visual sequences were presented unimodally and when auditory and visual sequences were correlated during training. However, increasing task demands resulted in an important asymmetry: Increased task demands attenuated visual statistical learning, while having no effect on auditory statistical learning. These findings are consistent with auditory dominance effects reported in young children and have important implications for our understanding of how sensory modalities interact while learning the structure of cross-modal informationScience on Google+ Posterside Hangouts #12013-08-13 02:30:0099G+
Science on Google+391,137Be curious. Question assumptions. Explore the world from atoms to astrophysics with Veritasium.Join +Derek Muller of popular +YouTube Channel Veritasium on a journey to the beautiful, viral side of physics, hosted by Science on Google+ in honor of YouTube Geek Week (Aug 4-10). Our +Amy Robinson, +Jason Davison and +Nic Hammond will host, along with +Joe Hanson of +It's Okay To Be Smart and a few members of the community who ask Derek interesting questions on the event page.  The hangout happens on Wednesday, August 7th at 5 pm US PT / 8 ET.Derek will share why he creates Veritasium and how it has evolved into one of YouTube’s favorite sources of answers to epic science questions. He’ll also answer your questions so leave them here on the event page. You may be selected to join the hangout live and ask him in person.  Check out Veritasium on YouTube at http://veritasium.com This is the third hangout in a new series that brings science to life through conversations with the world's leading minds. Join +Science on Google+: A Public Database for the latest events.Veritasium: A Science on Google+ Conversation2013-08-08 02:00:00238G+
Science on Google+391,137"There's a lot of amazing science out there. Let's go discover it together." Join Dr. +Joe Hanson  biologist and host of popular YouTube/ +PBS Digital Studios series +It's Okay To Be Smart  + +AAAS  Mass Media Fellow at +WIRED  on a journey to the awesome side of science. This hangout will be hosted by Science on Google+'s +Amy Robinson , +Jason Davison   and +Nic Hammond   .The hangout happens on Monday, July 22rd at NOON PT/ 3 PM ET. Joe will answer your questions and give insights on bringing science to the masses, the power of YouTube, why GIFs are awesome and much more. Add your thoughts and questions for Joe on this page. Joe will invite a few insightful fans to join the hangout in person!Get to know Dr Joe: check out his blog at http://www.itsokaytobesmart.com/This is the second hangout in a new series that brings science to life through conversations with the world's leading minds. Subscribe to the Science on Google+ communities for the latest.It's Okay To Be Smart: A Science on Google+ Conversation2013-07-22 21:00:00121G+
Amy Robinson28,295On June 13 the U.S. Supreme Court made a landmark decision, unanimously ruling that human genes may not be patented.  What does that mean for you and me?Join geneticist +Ian Bosdet  and the +Science on Google+: A Public Database  Community for a 30 minute conversation to discuss what this ruling may mean for the future of health and genetic research. This event will be hosted by +Amy Robinson and +Nic Hammond .Ask questions for Ian to answer On Air and share your thoughts on the event page. Ian and the Science on Google+ team will invite a few insightful guests to ask their questions live in the hangout. Gene Patenting: A Google+ Science Conversation2013-07-09 21:00:0063G+
ScienceSunday80,399Join hosts +Buddhini Samarasinghe and +Scott Lewis  for another “SciSunHOA”, a live Google+ Hangout On Air broadcast, brought to you by +ScienceSunday. This episode, Professor +Vincent Racaniello joins Buddhini and Scott to discuss his work in virology. Vincent is a professor of microbiology and immunology at Columbia University. His research includes the study of poliovirus (Polio), rhinovirus (Common Cold), and other RNA viruses. His work focuses on how our immune systems interact with these viruses, how they cause disease, while also discovering new viruses in wild animals.Outside of the lab, Vincent is involved in many science outreach efforts, including hosting the excellent podcast series This Week in Virology (TWiV). You can read more on his website here (http://www.virology.ws/) We’re all very excited for this episode of “SciSunHOA” as Vincent is not only a brilliant scientist, but also an outstanding science communicator!Questions for Vincent, Buddhini and Scott can be left here in the event page, as well as during the live show through the shares of the HOA, including on Twitter using the hash tag: #SciSunHOA  Going Viral: #SciSun Hangout on Air featuring Vincent Racaniello2013-04-29 00:00:0059G+
Jeanne Garbarino137,557This purpose of this hangout is to help promote Brain Awareness Week (BAW), as well as breakdown neuroscience research for public consumption.  BAW is spearheaded by the Dana Foundation and the Society for Neuroscience.Be BraiNY: A conversation with neuroscientists Carol Mason and Moses Chao2013-03-06 20:00:0038G+
Fraser Cain896,596Join our team of space/astronomy journalists as we bring you a quick rundown of all the breaking space news this week. Professional journalists from Universe Today, SPACE.com, Discovery, Discover Magazine, NBC, and more.We'll talk about the latest missions, biggest discoveries, and more.Hosted by Fraser CainClick "Yes" to "Are you going" if you want to have this event automatically put into your calendar.Weekly Space Hangout - Oct. 11, 20122012-10-11 19:00:00253G+
Kiki Sanford3,094,079What do the Democratic and Republican Presidential candidates think about science? What are their stances on science policy issues? Why should science even be a part of our modern political conversations?Join Dr. Kiki (@113166718268343560861) and @103377423155109727835, CEO of ScienceDebate.org and author of 'Fool Me Twice', for a discussion of the candidates' answers to the important questions about climate change, research, energy, space, and more posed them by ScienceDebate.org.Contact @113166718268343560861 for comments and questions prior to the event.Science Debate 2012 - The Presidential Answers2012-09-12 00:00:0027G+

Ian Bosdet has been shared in 157 public circles

You can see here the 50 latest shared circles.
If this is your profile, you can check your dashboard to see all shared circles you have been included.

AuthorFollowersDateUsers in CircleCommentsReshares+1Links
Becky Collins15,192Recipes and Cooking Circle : Circle of very #social #engagerspeople and companiesTo be included in my shares (#sharedcircle), be so kind to:1 - Do +1 t the post2 - Comment the post and specify your "category" (job or interest) Ex: Fashion, SEO, Companies, Social Media Marketing, Sailing, Photography, Bloggers/Writers, Web graphics and design, Italy, Artists, Sport, Finance/Economy ...3 - include the circle among your circles4 - share the circle (include yourself)Improve your popularity, be social be cool !Keep yourself updated, enjoy the Shared Circles Hellenic Alliance, you can share your shared circles inside the upcoming Community:https://plus.google.com/communities/112552559573595396104  #socialmedia  #media  #circles   #circleshare   #circlesharing  #circlecircle   #beckyscircle   #sharedcircles   #sharedpubliccircles  #sharedcircleoftheday  +Becky Collins ?2014-08-18 05:14:39477028CC G+
Carlos Esteban50,970ENGAGERS and other INTERESTING PEOPLE Here you will find a sample of recent and repeat engagers, people that include me in shared circles, and people that publish interesting, useful or amusing posts. Add the circle and check them out. Maybe you like some of them! Feel free to re-share the circle :) Have a great week!2014-08-11 15:57:3149910684156CC G+
Becky Collins13,898Beer. Bacon. Music Circle :Circle of very #social #engagerspeople and companiesTo be included in my shares (#sharedcircle), be so kind to:1 - Do +1 t the post2 - Comment the post and specify your "category" (job or interest) Ex: Fashion, SEO, Companies, Social Media Marketing, Sailing, Photography, Bloggers/Writers, Web graphics and design, Italy, Artists, Sport, Finance/Economy ...3 - include the circle among your circles4 - share the circle (include yourself)Improve your popularity, be social be cool !Keep yourself updated, enjoy the Shared Circles Hellenic Alliance, you can share your shared circles inside the upcoming Community:https://plus.google.com/communities/112552559573595396104  #socialmedia  #media  #circles   #circleshare   #circlesharing  #circlecircle   #beckyscircle   #sharedcircles   #sharedpubliccircles  #sharedcircleoftheday  +Becky Collins ?2014-08-02 05:13:064683210CC G+
Aman Singh2,014Circle of the dayYour re-share is appreciatedPlease re-share this circle in your stream.To be added:1- Add +Circles Circles Circles to your circles2- Write the URL of your blog in the comments section below3- Your blog must be an active blog (posts must be current)2014-07-16 12:15:324990616CC G+
Ryan Johnson9,485Hi friends! This is a great circle created with an important selection from all circles. The most important engagers are reshared because only that way can we grow our circle and have the people of google circle us.To get in, and to ensure you stay in this circle you need to do the following:1. Add me to your circles, if you haven't done so already!2. +1 this circle!3. Publicly share this circle to public, your circles and extended circles.4. If possible, leave a comment on this circle so I know you have done the three steps above!#circleshare #circlesharing #circleoftheday #wanttobecircled #addmetoyourcircles #public #publiccircle #sharedcircles #Britain #sharedcircle #morefollowers #sharingcircles #sharedpubliccircles #sharedpublicircles #sharedcircle #photography #uk  #nottingham #Holland #Netherlands #Duch2014-07-16 10:40:014918812CC G+
Becky Collins10,439Super Science Circle :Circle of very #social #engagerspeople and companiesTo be included in my shares (#sharedcircle), be so kind to:1 - Do +1 t the post2 - Comment the post and specify your "category" (job or interest) Ex: Fashion, SEO, Companies, Social Media Marketing, Sailing, Photography, Bloggers/Writers, Web graphics and design, Italy, Artists, Sport, Finance/Economy ...3 - include the circle among your circles4 - share the circle (include yourself)Improve your popularity, be social be cool !Keep yourself updated, enjoy the Shared Circles Hellenic Alliance, you can share your shared circles inside the upcoming Community:https://plus.google.com/communities/112552559573595396104  #socialmedia  #media  #circles   #circleshare   #circlesharing  #circlecircle   #beckyscircle   #sharedcircles   #sharedpubliccircles  #sharedcircleoftheday  +Becky Collins ?2014-05-31 05:09:154901211CC G+
John Nuntiatio36,773#circles #sharedcircles #circlesharing #circle #bestcircle #news   #bestofcircles #bestcircleshare #share #tech #business #sport #small   #smallcircle #football #tennis #golf #photography #health #weightloss  2014-05-19 21:53:11494136CC G+
Farid Shaikh171No strings attached circle!If you want to be in the #circle  then let us know if you want to be in the circle! That's it! If you got notified, then you are in this one!2014-05-18 02:16:335017310CC G+
Farid Shaikh65Google Friends! - You're in this  #Circle   -  #Share   the circle *'"*:•:•* •-::-•:*:•-:¦: Share and Be  #Shared   :¦:-•:*:•.::• •-:•:''''*                                              115This is a super  #Circle   and in it I put together a group of really interesting and active people on Google Plus to add in your circles.I'm talking about the top   #Google + users that share unique and original contents.#Follow   this advice and grow your G+ community with people that share amazing content that will surprise you:#boost   visibility on Google+ - Share the circle!If you want to be added to the next Circle you have to do these simple steps:1 - Include me in your circles 3 - Share the circle (Publicly) 4 - Add +1 to the post 5 -  #Follow   your dreams and smile to life.More you share more you get! :)Thanks!#circles      #circleshare      #circlesharing      #sharedcircles                #addcircles    #addpeople      #addcircle    #addfriends      2014-05-17 06:20:0550110811CC G+
Carlos Esteban45,152ENGAGERS and other INTERESTING PEOPLE Here you will find a sample of recent and repeat engagers, people that include me in shared circles, and people that publish interesting, useful or amusing posts. Add the circle and check them out. Maybe you like some of them! Feel free to re-share the circle :) Have a great week! #circles #circlethis #circleyoushare #sharedcircles #addcircle #sharedpubliccircles #growfollowers #circleshare #publicsharedcircles #circleoftheweek #circlesharing #publiccircle #findcircles #circlemeup #sharedcircle #circleshare  #thursdaycircle   #thursdaycircleshared   #circlethursday #circle 2014#82014-05-12 13:43:52499150113187CC G+
John Nuntiatio36,016#circles #sharedcircles #circlesharing #circle #bestcircle #news   #bestofcircles #bestcircleshare #share #tech #business #sport #small   #smallcircle 2014-05-09 10:13:25362667CC G+
John Nuntiatio34,173#circles #share #sharedcircles #circlesharing #circle #bestcircle #news 2014-04-20 08:16:45245287CC G+
John Nuntiatio33,831#circles #share #sharedcircles #circlesharing #circle #bestcircle #news 2014-04-17 06:46:35484348CC G+
John Nuntiatio30,616#circles #sharedcircles #circlesharing #circle #circleoftheday #bestofcircles #bestcircleshare #share #tech #business #sport2014-03-21 20:51:17491000CC G+
John Nuntiatio30,616#circles #sharedcircles #circlesharing #circle #circleoftheday #bestofcircles #bestcircleshare #share #tech #business #sport2014-03-21 20:50:27491001CC G+
John Nuntiatio30,616#circles #sharedcircles #circlesharing #circle #circleoftheday #bestofcircles #bestcircleshare #share #tech #business #sport2014-03-21 20:49:43491004CC G+
John Nuntiatio30,616#circles #sharedcircles #circlesharing #circle #circleoftheday #bestofcircles #bestcircleshare #share #tech #business #sport2014-03-21 20:49:15491022CC G+
John Nuntiatio30,616#circles #sharedcircles #circlesharing #circle #circleoftheday #bestofcircles #bestcircleshare #share #tech #business #sport2014-03-21 20:48:03491527CC G+
Becky Collins5,164 Social Sciences Circle :Circle of very #social #engagerspeople and companiesTo be included in my shares (#sharedcircle), be so kind to:1 - Do +1 t the post2 - Comment the post and specify your "category" (job or interest) Ex: Fashion, SEO, Companies, Social Media Marketing, Sailing, Photography, Bloggers/Writers, Web graphics and design, Italy, Artists, Sport, Finance/Economy ...3 - include the circle among your circles4 - share the circle (include yourself)Improve your popularity, be social be cool !#socialmedia  #media  #circles   #circleshare   #circlesharing  #circlecircle   #beckyscircle   #sharedcircles   #sharedpubliccircles  #sharedcircleoftheday  +Becky Collins2014-03-18 12:35:31305008CC G+
Carlos Esteban39,158ENGAGERS and other INTERESTING PEOPLE Here you will find a sample of recent and repeat engagers, people that include me in shared circles, and people that publish interesting, useful or amusing posts. Add the circle and check them out. Maybe you like some of them! Feel free to re-share the circle :) Have a great Sunday! #circles #circlethis #circleyoushare #sharedcircles #addcircle #sharedpubliccircles #growfollowers #circleshare #publicsharedcircles #circleoftheweek #circlesharing #publiccircle #findcircles #circlemeup #sharedcircle #circleshare  #thursdaycircle   #thursdaycircleshared   #circlethursday #circle 2014#72014-03-16 14:11:22498604562CC G+
John Nuntiatio29,767#circles #sharedcircles #circlesharing #circle #circleoftheday #bestofcircles #bestcircleshare #share #tech #business #sport2014-03-14 06:27:36393014CC G+
John Nuntiatio29,767#circles #sharedcircles #circlesharing #circle #circleoftheday #bestofcircles #bestcircleshare #share #tech #business #sport2014-03-14 06:26:50393033CC G+
John Nuntiatio29,767#circles #sharedcircles #circlesharing #circle #circleoftheday #bestofcircles #bestcircleshare #share #tech #business #sport2014-03-14 06:26:17393011CC G+
John Nuntiatio29,767#circles #sharedcircles #circlesharing #circle #circleoftheday #bestofcircles #bestcircleshare #share #tech #business #sport2014-03-14 06:25:52393011CC G+
John Nuntiatio29,767#circles #sharedcircles #circlesharing #circle #circleoftheday #bestofcircles #bestcircleshare #share #tech #business #sport2014-03-14 06:25:16393203CC G+
Becky Collins3,213Baseball circle #Baseball  #circles   #circleshare   #circlesharing   #circlecircle   #beckyscircle   #sharedcircles   #sharedpubliccircles   #sharedcircleoftheday  +Becky Collins 2014-02-26 10:30:413883216CC G+
John Nuntiatio28,116circles #sharedcircles #circlesharing #circle #circleoftheday #newcircle #bestofcircles #bestcircleshare #share #tech #business #sport #health   #entertainment   #news  2014-02-23 08:38:002986725CC G+
Becky Collins2,634Marketing Circle : Feb 22#circles   #circleshare   #circlesharing   #circlecircle   #beckyscircle   #sharedcircles   #sharedpubliccircles   #sharedcircleoftheday +Becky Collins2014-02-22 06:29:4945517724CC G+
Carlos Esteban35,966ENGAGERS and other INTERESTING PEOPLE Here you will find: ►A sample of recent and repeat engagers with my posts on #science, #animals and #landscape pictures, #sciencefiction and #humor. ►Some people that include me in the circles that they curate… or that have not included me yet but I would love to be :) ►And some people that publish interesting, useful or amusing posts regardless if they circle me back or not. The categories are not exclusive and many people are in more than one. Add the circle and check them out. Maybe you like some of them! Feel free to re-share the circle if you wish. I will appreciate it. Have a nice Valentine’s day!Carlos #circles #circlethis #circleyoushare #sharedcircles #addcircle #sharedpubliccircles #growfollowers #circleshare #publicsharedcircles #circleoftheweek #circlesharing #publiccircle #findcircles #circlemeup #sharedcircle #circleshare  #thursdaycircle   #thursdaycircleshared   #circlethursday #circle 2014#62014-02-14 19:25:01464614865CC G+
Carlos Esteban33,566ENGAGERS and other INTERESTING PEOPLE Here you will find: -A sample of recent and repeat engagers with my posts on #science , #animals and #landscape pictures, #sciencefiction and #humor . -Some people that include me in the circles that they curate… or that have not included me yet but I would love to be :) -And some people that publish interesting, useful or amusing posts regardless if they circle me back or not. The categories are not exclusive and many people are in more than one. Add the circle and check them out. Maybe you like some of them! Feel free to re-share the circle if you wish. I will appreciate it. Have a nice Sunday!Carlos #circles #circlethis #circleyoushare #sharedcircles #addcircle #sharedpubliccircles #growfollowers #circleshare #publicsharedcircles #circleoftheweek #circlesharing #publiccircle #findcircles #circlemeup #sharedcircle #circleshare   #thursdaycircle    #thursdaycircleshared    #circlethursday #circle  2014#42014-01-26 13:53:24495160145197CC G+
John Nuntiatio25,447#circles #sharedcircles #circlesharing #circle #circleoftheday #bestofcircles #bestcircleshare #share #tech #business #sport2014-01-25 19:41:45255729CC G+
Nina Pelletier16,409Thought today would be a good day to share my Canadian Circle .  Some of the very best Canucks are right here on G+ with us :)2014-01-25 19:12:58471215CC G+
Christy Sandhoff27,208This is a very nice circle Carlos.  Thanks for posting it. ==========================================Carlos Esteban - Google+ - ENGAGERS and other INTERESTING PEOPLE Here you will find...ENGAGERS and other INTERESTING PEOPLE Here you will find recent and repeat engagers, people that include me in shared circles, and people that publish interesting, useful or amusing posts. Add the circle and check them out. Maybe you like some of them! Feel free to re-share the circle if you wish :) Have a great weekend!2014-01-17 22:22:5740171114CC G+
Carlos Esteban32,281ENGAGERS and other INTERESTING PEOPLE Here you will find recent and repeat engagers, people that include me in shared circles, and people that publish interesting, useful or amusing posts. Add the circle and check them out. Maybe you like some of them! Feel free to re-share the circle if you wish. I will appreciate it. Have a nice day!Carlos 2014#3#circles #circlethis #circleyoushare #sharedcircles #addcircle #sharedpubliccircles #growfollowers #circleshare #publicsharedcircles #circleoftheweek #circlesharing #publiccircle #findcircles #circlemeup #sharedcircle #circleshare  #thursdaycircle   #thursdaycircleshared   #circlethursday #circle2014-01-16 13:53:50491129124180CC G+
James Harper726+Carlos Esteban originally shared: ENGAGERS and other INTERESTING PEOPLE Here you will find recent and repeat engagers, people that include me in shared circles, and people that publish interesting, useful or amusing posts. Add the circle and check them out. Maybe you like some of them! Feel free to re-share the circle if you wish :) Have a great weekend! #circles #circlethis #circleyoushare #sharedcircles #addcircle #sharedpubliccircles #growfollowers #circleshare #publicsharedcircles #circleoftheweek #circlesharing #publiccircle #findcircles #circlemeup #sharedcircle #circleshare   #thursdaycircle   #thursdaycircleshared   #circlethursday #circle 2014-01-11 00:11:5845612426CC G+
Christy Sandhoff26,446Shared by Carlos Esteban..... ENGAGERS and other INTERESTING PEOPLE Here you will find recent and repeat engagers, people that include me in shared circles, and people that publish interesting, useful or amusing posts. Add the circle and check them out. Maybe you like some of them! Feel free to re-share the circle if you wish :) Have a great weekend!2014-01-10 17:39:29451161029CC G+
Carlos Esteban31,485ENGAGERS and other INTERESTING PEOPLE Here you will find recent and repeat engagers, people that include me in shared circles, and people that publish interesting, useful or amusing posts. Add the circle and check them out. Maybe you like some of them! Feel free to re-share the circle if you wish :) Have a great weekend! #circles #circlethis #circleyoushare #sharedcircles #addcircle #sharedpubliccircles #growfollowers #circleshare #publicsharedcircles #circleoftheweek #circlesharing #publiccircle #findcircles #circlemeup #sharedcircle #circleshare  #thursdaycircle   #thursdaycircleshared   #circlethursday #circle2014-01-10 17:31:474549462142CC G+
Cyrus Khan15,832 *Active Engager's Circle*If you've received a notification, it means you are a part of the circle.Please re-share the circle to increase the exposure of all these friendly and interactive people.Thanks for interacting : )  This is the next edition of my weekly Engagers circle, where I highlight and share the people who've interacted with me this week.I will share this circle to all my followers for exposure as an personally approved group.The criteria to be added are:1)You have commented on and publicly shared one or more of my posts;2) You have re-shared this weeks circle;As this circle grows, I may have difficulty accommodating everyone, so if you add and re-share this week's circle, you'll be guaranteed a spot in next week's edition.Cheers! #circleshare   #active   #engagers   #science   #sciencecircle  2014-01-04 22:40:36476463690CC G+
Carlos Esteban30,646ENGAGERS + INTERESTING PEOPLE So here is my first circle of 2014… actually my first circle ever! This is the first time that I create and share a circle. Here you will find recent engagers and people that publish interesting, useful or amusing posts. Maybe you like some of them. Happy New Year! #circles #circlethis #circleyoushare #sharedcircles #addcircle #sharedpubliccircles #growfollowers #circleshare #publicsharedcircles #circleoftheweek #circlesharing #publiccircle #findcircles #circlemeup #sharedcircle #circleshare  #thursdaycircle   #thursdaycircleshared   #circlethursday #circle2014-01-01 13:25:133659245138CC G+
Cyrus Khan15,016Active Engager's CircleIf you've received a notification, it means you are a part of the circle.Thanks for interacting : )  This is the next edition of my weekly Engagers circle, where I highlight and share the people who've interacted with me this week.I will share this circle to all my followers for exposure as an personally approved group.The criteria to be added are:1)You have commented on and publicly shared one or more of my posts;2) You have re-shared this weeks circle;As this circle grows, I may have difficulty accommodating everyone, so if you add and re-share this week's circle, you'll be guaranteed a spot in next week's edition.Cheers! #circleshare   #active   #engagerscircle   #science   #sciencecircle  2013-12-05 18:31:07494532387CC G+
Kyle Pearce116A great Google+ Circle of Educators!  2013-11-24 15:10:12501606CC G+
Lo Sauer2,493This is a great circle combined of active engagers, creative folks and  some of the best and brightest people on google+. A thank you in this circle-inclusion-shoutout to: +Peter Terren +Michael Műller +Carlos Esteban +Justin Chung +Malthus John +Marta Rauch +Rajini Rao +Katherine Vucicevic +Jonathan Eisen +Mike Allton +Scott Buehler +Mario Falcetti +Zvonimir Fras +Krithika Rangarajan +sridhar krishnan +Joanna Ortynska +Seamus Smyth +Chuck Croll +Michael Schobel +2013-11-19 18:19:4843218317CC G+
Rank Kemeng0This is a group of individuals that has personally shared four of my best circle sharing circles in the last month (or so).  They also include a mix of new circle sharers and some that are just trying to learn it for the first time. :) :) :0)They are individuals, to a large degree, that are very interested in not just circle sharing (which is great), but also engaging with you in a meaningful way (which is awesome)!!!Guidelines for Core Multipliers- Share the circle to stay in the circle- Have some fun!- If you are new and want in the circle, share the circle.This is a great group.  Enjoy this circle and have an awesome Thursday!*if you were somehow missed/ not included in the circle, please let me know and it will be corrected on the next share. My apologies ahead of time! :)**For those coming from multiplying circle, we are not inviting new folks here, you can privately message them or ping them when you share the circle on your public feed. Thanks!#corecircle #multiplyingcircle #coremultipliers #sharedcircles #circleshare #bestsharedcircle   #circleshare   #sharedcircles   #circleoftheday   #CircleQueen   #CircleMaster   #GPlusList   #Circle   #Circleshare   #Circlesharing   #PublicSharedCircles2013-11-01 15:53:38426115CC G+
Coyeb Sundel02013-10-24 10:04:35425202CC G+
Tiberiu Igrisan448Science (part 1)#science #sciencecircle #sharedcircles  2013-10-14 18:53:04257123CC G+
Fabian Weiland393#sharedcircle #sharedcircles #health #wellness  2013-10-14 15:30:25243000CC G+
James Steward1,112These are awesome scientist friends who comment my posts#scientistcirle #circle #circleshared #sharedcircle #circleoftheday #followfriday2013-10-10 16:30:23414103CC G+
James Steward1,112These are awesome scientist friends who comment my posts#scientistcirle #circle #circleshared #sharedcircle #circleoftheday #followfriday2013-10-10 16:29:39414003CC G+
James Steward1,112These are awesome scientist friends who comment my posts#scientistcirle #circle #circleshared #sharedcircle #circleoftheday #followfriday2013-10-10 16:29:27414002CC G+
James Steward1,112These are awesome scientist friends who comment my posts#scientistcirle #circle #circleshared #sharedcircle #circleoftheday #followfriday2013-10-10 16:29:04414002CC G+

Activity

Average numbers for the latest posts (max. 50 posts, posted within the last 4 weeks)

2
comments per post
1
reshares per post
16
+1's per post

376
characters per posting

Top posts in the last 50 posts

Most comments: 40

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2014-07-04 16:42:07 (40 comments, 6 reshares, 38 +1s)

Get your copy today before they're all gone!

(h/t: Orac)

Most reshares: 26

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2014-05-08 20:08:41 (2 comments, 26 reshares, 32 +1s)

Victory is ours

---
Edit: Thanks to +Mary Mangan for pointing out that you can buy this poster: https://www.etsy.com/ca/listing/96789618/world-war-ii-dinosaur-poster

Most plusones: 76

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2014-04-07 05:47:47 (3 comments, 22 reshares, 76 +1s)

Nicely said, +Cara Santa Maria. 

Latest 50 posts

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2014-08-12 05:27:48 (0 comments, 4 reshares, 47 +1s)

Dammit

"You'll have bad times, but it'll always wake you up to the good stuff you weren't paying attention to." -- Robin Williams

This quote couldn't be more relevant to me right now. And as a generally bubbly, giddy person who's experienced depression, I'm not surprised to hear that Robin Williams was fighting severe depression. What I am is very sad, though. :( I'll miss him and his work -- and not just the funny parts.___Dammit

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2014-08-06 23:58:35 (0 comments, 0 reshares, 2 +1s)

"Since the Ebola outbreak began in February, around 300,000 people have died from malaria, while tuberculosis has likely claimed over 600,000 lives. Ebola might have our attention, but it’s not even close to being the biggest problem in Africa right now. Even Lassa fever, which shares many of the terrifying symptoms of Ebola (including bleeding from the eyelids), kills many more than Ebola – and frequently finds its way to the US."

"Since the Ebola outbreak began in February, around 300,000 people have died from malaria, while tuberculosis has likely claimed over 600,000 lives. Ebola might have our attention, but it’s not even close to being the biggest problem in Africa right now. Even Lassa fever, which shares many of the terrifying symptoms of Ebola (including bleeding from the eyelids), kills many more than Ebola – and frequently finds its way to the US."___

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2014-08-06 21:17:03 (4 comments, 0 reshares, 8 +1s)

Whereas everything +Tara C. Smith knows about Ebola is right.  Read below for some real facts about the disease and hear her calm, expert opinion telling us not freak out.

Whereas everything +Tara C. Smith knows about Ebola is right.  Read below for some real facts about the disease and hear her calm, expert opinion telling us not freak out.___

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2014-07-31 16:52:47 (3 comments, 0 reshares, 11 +1s)

___

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2014-07-28 23:15:46 (3 comments, 3 reshares, 13 +1s)

RRRRRRUUUUUUNNNNN!!!!

Do you want to start running to improve your health but lack the free time required?  Good news - not that much free time is required!  

This study found that almost any running, even slowly for about 5-10 minutes/day, provided 30% and 45% lower adjusted risks of all-cause and cardiovascular mortality, and added a 3 year life expectancy benefit.

So, get out there!

http://content.onlinejacc.org/article.aspx?articleID=1891600

RRRRRRUUUUUUNNNNN!!!!

Do you want to start running to improve your health but lack the free time required?  Good news - not that much free time is required!  

This study found that almost any running, even slowly for about 5-10 minutes/day, provided 30% and 45% lower adjusted risks of all-cause and cardiovascular mortality, and added a 3 year life expectancy benefit.

So, get out there!

http://content.onlinejacc.org/article.aspx?articleID=1891600___

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2014-07-09 21:12:23 (1 comments, 0 reshares, 10 +1s)

the dense and widespread deposits of jacketed lead and copper in the air pose severe and potentially fatal health risks to all Chicago residents

the dense and widespread deposits of jacketed lead and copper in the air pose severe and potentially fatal health risks to all Chicago residents___

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2014-07-04 16:42:07 (40 comments, 6 reshares, 38 +1s)

Get your copy today before they're all gone!

(h/t: Orac)

Get your copy today before they're all gone!

(h/t: Orac)___

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2014-06-26 18:05:57 (1 comments, 0 reshares, 14 +1s)

Rosco Cypress

Burrard Inlet, Vancouver

Rosco Cypress

Burrard Inlet, Vancouver___

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2014-06-26 17:58:52 (3 comments, 2 reshares, 16 +1s)

Rosco Cypress

Burrard Inlet, Vancouver

Rosco Cypress

Burrard Inlet, Vancouver___

2014-06-26 16:55:17 (0 comments, 0 reshares, 3 +1s)

I had no real insight for +Joanne Manaster.  Has anyone else tried out the new Google Genomics tools yet?  Any thoughts?

Calling +Mary Mangan and +Ian Bosdet and other genomics/bioinformatics people
What is this? Will researchers be using this? 
https://developers.google.com/genomics/___I had no real insight for +Joanne Manaster.  Has anyone else tried out the new Google Genomics tools yet?  Any thoughts?

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2014-06-13 17:52:55 (6 comments, 0 reshares, 11 +1s)

Vancouver Science World

Vancouver Science World___

2014-06-02 18:06:00 (0 comments, 0 reshares, 3 +1s)

So is #OSX10 #Yosemite going to be referred to as OS XY?  Seems perhaps a bit male-centric...

So is #OSX10 #Yosemite going to be referred to as OS XY?  Seems perhaps a bit male-centric...___

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2014-06-01 17:06:42 (1 comments, 0 reshares, 1 +1s)

Great post by +Rajini Rao. Are viruses the future of antibacterial therapy?

The Enemy of My Enemy

✇ Nearly 125 years ago, a British bacteriologist observed that the holy waters of the Ganges and Yamuna had curious bactericidal properties, limiting the spread of cholera. It took another 20 years before two microbiologists independently proposed the existence of viruses. Observing small clearings on a lawn of dysentery-causing bacillus on an agar plate, d'Herelle coined the term bacteriophage for the virus that devours bacteria; now affectionately abbreviated to "phage".  

A Voracious Appetite: Found everywhere bacteria exist- in the soil, deep inside the earth's crust, within the bodies of animals and plants, and densely packed in the oceans, there are an estimated 1×10^8 different types of phages, each infecting only a specific type of bacteria.  Almost comical in appearance, a phage has its genetic material tightly packed into the capsid head, that can be injected through the stalk-like tail into the bacterial cell. Once inside, it can stage a peaceful coup (lysogenic) or burst open the bacterium (lytic) when it multiplies. It is estimated that there are up to 10^32 phages in our biosphere, destroying half the bacterial population every 48 hours! 

Microbe Hunters: d'Herelle and his fellow scientists were quick to grasp the potential of phages as antibacterials. After consuming a preparation to confirm its safety, he administered the phage to a 12-year old boy with acute dysentery. The boy fully recovered. This set off a golden era in the commercial production and use of phages, centered largely in eastern Europe and Russia. In the 1940's, companies like L'Oreal and Eli Lilly marketed products with catchy names like Bacté-coli-phage and Staphylo-gel! There were set backs (d'Herelle's science partner in Tbilisi was executed by Stalin) and with the discovery of antibiotics in the 1940's, Western scientists lost interest in this line of medical research. Unfortunately, most published studies (written in Russian or Georgian) are not accessible to the western world and clinical trials did not follow current protocols of controls, making them difficult to assess retrospectively. 

Evolutionary Arms Race: With growing resistance to antibiotics, a resurgence in phage therapy may be warranted. One advantage to phage therapy is that when bacteria develop resistance to a phage, we should be able to rapidly select (in a few days or weeks) for mutant phage versions in a tit-for-tat evolutionary arms race! Phage therapy is already around us in some form:the USDA has approved a phage spray (ListShield) that can be used on cheese, chicken, and processed meat to prevent infection with Listeria. Is this the start of a new phage in the way we treat bacterial infections? :)

REF: (1) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC90351/#B21
(2) http://cid.oxfordjournals.org/content/48/8/1096.full

Image: T-phage infecting E. coli , false-colored EM via http://goo.gl/fmDVCi

#ScienceSunday  ___Great post by +Rajini Rao. Are viruses the future of antibacterial therapy?

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2014-05-29 22:21:20 (0 comments, 0 reshares, 4 +1s)

Setback for the skin cancer industry 

Setback for the skin cancer industry ___

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2014-05-27 20:14:37 (0 comments, 0 reshares, 4 +1s)

Canon 6D
24-105 f/4L
Vancouver, Canada

___Canon 6D
24-105 f/4L
Vancouver, Canada

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2014-05-27 19:34:28 (6 comments, 0 reshares, 3 +1s)

Nearly 20 members of the woman’s family, including her father and brothers, attacked her and her husband with batons and bricks in broad daylight before a crowd of onlookers in front of the high court of Lahore

Nearly 20 members of the woman’s family, including her father and brothers, attacked her and her husband with batons and bricks in broad daylight before a crowd of onlookers in front of the high court of Lahore___

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2014-05-27 05:21:28 (1 comments, 2 reshares, 12 +1s)

___

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2014-05-27 05:01:31 (0 comments, 0 reshares, 4 +1s)

___

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2014-05-24 01:04:22 (0 comments, 0 reshares, 2 +1s)

Free the (BRCA) Data

The Free the Data campaign (http://www.free-the-data.org/) is working to help transfer BRCA1 and BRCA2 mutation information into the public domain.  Anyone who has received BRCA mutation testing can upload their report and have it added (anonymously) into the public clinical variant database.

Below is an inspiring video about the campaign and some of the first people to participate.  My friend and colleague +Martin Krzywinski was invited to act as an educator and helped to document the meeting.

Free the (BRCA) Data

The Free the Data campaign (http://www.free-the-data.org/) is working to help transfer BRCA1 and BRCA2 mutation information into the public domain.  Anyone who has received BRCA mutation testing can upload their report and have it added (anonymously) into the public clinical variant database.

Below is an inspiring video about the campaign and some of the first people to participate.  My friend and colleague +Martin Krzywinski was invited to act as an educator and helped to document the meeting.___

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2014-05-23 23:41:11 (0 comments, 2 reshares, 11 +1s)

Free the (BRCA) Data

The Free the Data campaign (http://www.free-the-data.org/) is working to help transfer BRCA1 and BRCA2 mutation information into the public domain.  Anyone who has received BRCA mutation testing can upload their report and have it added (anonymously) into the public clinical variant database.

Below is an inspiring video about the campaign and some of the first people to participate.  My friend and colleague +Martin Krzywinski was invited to act as an educator and helped to document the meeting.

Free the (BRCA) Data

The Free the Data campaign (http://www.free-the-data.org/) is working to help transfer BRCA1 and BRCA2 mutation information into the public domain.  Anyone who has received BRCA mutation testing can upload their report and have it added (anonymously) into the public clinical variant database.

Below is an inspiring video about the campaign and some of the first people to participate.  My friend and colleague +Martin Krzywinski was invited to act as an educator and helped to document the meeting.___

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2014-05-22 03:48:03 (5 comments, 10 reshares, 7 +1s)

Facebook, NSA-style

Facebook's new mobile app will listen and determine what music or TV show is playing in the vicinity of the user.  How can anyone think this is a good idea?

And the opt-out isn't much of one: Even if users decide not to share what they’re hearing or watching, Facebook will hold onto the data in anonymous form, keeping tabs on how many users watched particular shows. 

Facebook, NSA-style

Facebook's new mobile app will listen and determine what music or TV show is playing in the vicinity of the user.  How can anyone think this is a good idea?

And the opt-out isn't much of one: Even if users decide not to share what they’re hearing or watching, Facebook will hold onto the data in anonymous form, keeping tabs on how many users watched particular shows. ___

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2014-05-17 19:54:34 (0 comments, 0 reshares, 14 +1s)

___

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2014-05-11 19:20:41 (0 comments, 0 reshares, 2 +1s)

Bilateral prophylactic mastectomy
Kelly Rothe decided to get a bilateral prophylactic mastectomy, i.e. preventative removal of both breasts. She's a big Red Wings fan (who isn't) and in particular, a big fan of goaltender Jimmy Howard. Because the Red Wings organization is so classy, the video below shows what they did for this young lady.

The rest of this post focuses on the science. You may recall that kerfuffle when Angelina Jolie decided to get a bilateral prophylactic mastectomy. So here is some info and links to hopefully inform you a bit more. 

I'm not sure where Kelly get the 85% risk from. However, the risk is certainly higher for some women with specific genetic profiles.
In two studies, the estimated risks of developing breast cancer by age 70 years were 55 to 65 percent for women who carry a deleterious mutation in the BRCA1 gene and 45 to 47p... more »

Bilateral prophylactic mastectomy
Kelly Rothe decided to get a bilateral prophylactic mastectomy, i.e. preventative removal of both breasts. She's a big Red Wings fan (who isn't) and in particular, a big fan of goaltender Jimmy Howard. Because the Red Wings organization is so classy, the video below shows what they did for this young lady.

The rest of this post focuses on the science. You may recall that kerfuffle when Angelina Jolie decided to get a bilateral prophylactic mastectomy. So here is some info and links to hopefully inform you a bit more. 

I'm not sure where Kelly get the 85% risk from. However, the risk is certainly higher for some women with specific genetic profiles.
In two studies, the estimated risks of developing breast cancer by age 70 years were 55 to 65 percent for women who carry a deleterious mutation in the BRCA1 gene and 45 to 47 percent for women who carry a deleterious mutation in the BRCA2 gene (6,7). Estimates of the lifetime risk of breast cancer for women with Cowden syndrome, which is caused by certain mutations in the PTEN gene, range from 25 to 50 percent (8,9) or higher (10), and for women with Li-Fraumeni syndrome, which is caused by certain mutations in the TP53 gene, from 49 to 60 percent (11). (By contrast, the lifetime risk of breast cancer for the average American woman is about 12 percent.)
http://www.cancer.gov/cancertopics/factsheet/Therapy/risk-reducing-surgery

Why do BRCA1 mutations cause primarily breast and ovarian cancers?
http://goo.gl/jTpcXA via +Ian Bosdet

Breast Cancer Signs & Symptoms
http://goo.gl/ScqWsk via +Letha McGarity

Bras and Breast Cancer
http://goo.gl/FNqrnS via +Buddhini Samarasinghe

Salty MRI
https://plus.google.com/u/0/+ChadHaney/posts/VJ2k6h2taRQ

At a seminar about BRCA1 and BRCA2, Dr. Olopade shared a story about finding women in South America that had unknown Jewish ancestors from Spain. The South American women were carriers of BRCA mutations and did not know that their Jewish ancestors fled from Spain to South America.

Haplotype structure in Ashkenazi Jewish BRCA1 and BRCA2 mutation carriers.
http://www.ncbi.nlm.nih.gov/pubmed/21597964

Ashkenazi Jews
http://www.jewfaq.org/ashkseph.htm

#ScienceSunday  ___

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2014-05-10 04:17:25 (0 comments, 7 reshares, 5 +1s)

This is a short, funny, very well done tale of the devastation of a world. Very Godzilla-esque. 

This is a short, funny, very well done tale of the devastation of a world. Very Godzilla-esque. ___

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2014-05-08 22:57:43 (12 comments, 19 reshares, 18 +1s)

Why do BRCA1 mutations cause primarily breast and ovarian cancers?

Today, May 8th, is #WorldOvarianCancerDay and I started thinking again about the above question.  Why is it that mutations in BRCA1 and BRCA2 predispose to developing breast or ovarian cancer but usually not cancers in other tissues?  Patients sometimes ask this during a genetic counselling session and it's an astute question and a reasonable thing to ask but I haven't yet found a great answer.  Commonly it's a combination of "we don't really know" and a more involved discussion that "some cell types are more dependent upon some genes than others, and BRCA1 and BRCA2 seem to be very important for preventing cancer development in breast and ovarian tissue".  Both of these are correct but I think that they are as unsatisfying to give as they probably are to receive.  What is specialabou... more »

Why do BRCA1 mutations cause primarily breast and ovarian cancers?

Today, May 8th, is #WorldOvarianCancerDay and I started thinking again about the above question.  Why is it that mutations in BRCA1 and BRCA2 predispose to developing breast or ovarian cancer but usually not cancers in other tissues?  Patients sometimes ask this during a genetic counselling session and it's an astute question and a reasonable thing to ask but I haven't yet found a great answer.  Commonly it's a combination of "we don't really know" and a more involved discussion that "some cell types are more dependent upon some genes than others, and BRCA1 and BRCA2 seem to be very important for preventing cancer development in breast and ovarian tissue".  Both of these are correct but I think that they are as unsatisfying to give as they probably are to receive.  What is special about these genes and these tissues that links them together?

We know that BRCA1 and BRCA2 proteins have important roles in the DNA damage response.  Your chromosomes are under daily assault from all types of mutagens and stresses and they suffer a variety of damage types.  One of the worst types of damage is a double-stranded break, and BRCA1 and BRCA2 are important regulators of the double-stranded break repair pathways.  Failure to fix these errors can lead to genome instability, one of the hallmarks of cancer (for more detail see Part 7 of +Buddhini Samarasinghe wonderful series here: http://blogs.scientificamerican.com/guest-blog/2013/11/26/the-hallmarks-of-cancer-7-genome-instability-and-mutation/).  So, the role of BRCA genes as important tumor suppressors is well understood, but it still doesn't explain why deficiencies in these proteins lead almost exclusively to breast and ovarian tumors.

The rather obvious thing to wonder is whether estrogen plays a role; this hormone is important for the growth and development of both breast and ovarian tissues, which are exposed to relatively high concentrations of estrogen.  But BRCA1 breast tumors are commonly estrogen-receptor negative, meaning that the cancerous cells don't express or depend on the protein that senses estrogen and communicates this signal into the cell.  So it's not a simple "tumor uses hormone signaling to promote it's growth" situation, but perhaps it is some other aspect of high estrogen levels that promotes these cancers.  Which brings us (finally) to the recent research linked to below. The authors have investigated the relationship between estrogen metabolism, DNA damage and the BRCA1 protein.  Their results (and those of other groups working on the same problem) provide a possible answer answer to the link between estrogen and BRCA1:

-metabolites of estrogen can directly cause DNA damage by creating DNA adducts (molecules bound directly to the DNA nucleotides, interfering with DNA structure)
-DNA replication can't proceed past these damaged nucleotides (i.e. the replication fork stalls) and BRCA1 is required to repair the damage
-and, BRCA1 directly suppresses the expression of an enzyme (CYP1A1) that helps to produce the damaging estrogen metabolites (although BRCA2 doesn't appear to do this)

So: less BRCA1 protein leads to both 1) the increased production of damaging estrogen metabolites, and 2) the decreased ability to repair the DNA damage these molecules create.  If these results can be replicated then they may finally provide an interesting and more satisfying answer to why BRCA1 and BRCA2 mutations lead to breast and ovarian tumors.

The paper, for those with institutional access, is here:

BRCA1 DEFICIENCY EXACERBATES ESTROGEN INDUCED DNA DAMAGE AND GENOMIC INSTABILITY
Cancer Research doi: 10.1158/0008-5472.CAN-13-2611
http://cancerres.aacrjournals.org/content/early/2014/03/15/0008-5472.CAN-13-2611.short___

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2014-05-08 20:08:41 (2 comments, 26 reshares, 32 +1s)

Victory is ours

---
Edit: Thanks to +Mary Mangan for pointing out that you can buy this poster: https://www.etsy.com/ca/listing/96789618/world-war-ii-dinosaur-poster

Victory is ours

---
Edit: Thanks to +Mary Mangan for pointing out that you can buy this poster: https://www.etsy.com/ca/listing/96789618/world-war-ii-dinosaur-poster___

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2014-05-08 19:16:15 (1 comments, 1 reshares, 3 +1s)

Few women at high-risk for hereditary breast and ovarian cancer receive genetic counseling

This is a small but still disturbing report on how rarely women with hereditary risk for #BRCA1  and #BRCA2  cancers are receiving genetic counselling:

Among the 22 participants meeting the criteria for BRCA counseling and testing, only one self-reported meeting with a genetic counselor to discuss cancer risks occurred, and this person did not have genetic testing. Another person meeting high-risk criteria reported having genetic testing for cancer risk, but did not meet with a genetic counselor.

Overall, perceived cancer risk was higher among women with familial cancer risk (Table 3). Still, 27 % of women with familial breast/ovarian cancer felt their risk was “low”, and 32 % felt their risk was lower than average.

Few women at high-risk for hereditary breast and ovarian cancer receive genetic counseling

This is a small but still disturbing report on how rarely women with hereditary risk for #BRCA1  and #BRCA2  cancers are receiving genetic counselling:

Among the 22 participants meeting the criteria for BRCA counseling and testing, only one self-reported meeting with a genetic counselor to discuss cancer risks occurred, and this person did not have genetic testing. Another person meeting high-risk criteria reported having genetic testing for cancer risk, but did not meet with a genetic counselor.

Overall, perceived cancer risk was higher among women with familial cancer risk (Table 3). Still, 27 % of women with familial breast/ovarian cancer felt their risk was “low”, and 32 % felt their risk was lower than average.___

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2014-05-05 16:48:24 (9 comments, 7 reshares, 9 +1s)

Half a billion dollars to chiropractors

This is a stunning amount. It dwarfs the funding that NIH wastes on alternative medicine through NCCAM, which is itself an egregious waste of money.

Canada too spends millions on chiropractic, naturopathy, acupuncture and similar treatments, so it's not a US problem specifically.

Half a billion dollars to chiropractors

This is a stunning amount. It dwarfs the funding that NIH wastes on alternative medicine through NCCAM, which is itself an egregious waste of money.

Canada too spends millions on chiropractic, naturopathy, acupuncture and similar treatments, so it's not a US problem specifically.___

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2014-05-05 05:14:23 (0 comments, 0 reshares, 0 +1s)

Finally made a guide for How to Play +EyeWire 

Finally made a guide for How to Play +EyeWire ___

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2014-05-04 21:01:37 (7 comments, 3 reshares, 3 +1s)

Genetics Quiz

Who wants to try a risk calculation?

I-1 was affected with Hemophilia (Factor VIII deficiency). What is the probability that the pregnancy (IV-4) will result in a boy affected with Hemophilia?

A) 1/4
B) 1/8
C) 1/9
D) 1/18
E) 1/36

-----
ANSWER:

This question is an example of how Bayesian statistics are used for genetic risk calculations.  Hemophilia is on the X chromosome, which is why it is almost always males who have the disease.  II-1 definitely gets her dad's X chromosome, so she's definitely a carrier, and so her daughter (III-1) has a 50:50 chance of getting it from her.  

So III-1 has 1/2 chance of carrying Hemophilia A and 1/2 chance of not.  But she also has three normal sons, and each one of those slightly reduces her chance of actually being a carrier, since three normalson... more »

Genetics Quiz

Who wants to try a risk calculation?

I-1 was affected with Hemophilia (Factor VIII deficiency). What is the probability that the pregnancy (IV-4) will result in a boy affected with Hemophilia?

A) 1/4
B) 1/8
C) 1/9
D) 1/18
E) 1/36

-----
ANSWER:

This question is an example of how Bayesian statistics are used for genetic risk calculations.  Hemophilia is on the X chromosome, which is why it is almost always males who have the disease.  II-1 definitely gets her dad's X chromosome, so she's definitely a carrier, and so her daughter (III-1) has a 50:50 chance of getting it from her.  

So III-1 has 1/2 chance of carrying Hemophilia A and 1/2 chance of not.  But she also has three normal sons, and each one of those slightly reduces her chance of actually being a carrier, since three normal sons would only happen 1/8th of the time if she was a carrier.  So they actually reduce her carrier risk to 1/9.  So the risk of having an affected boy is 1/9 * 1/2 (chance she passes on the X) * 1/2 (chance her pregnancy is a boy) = 1/36___

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2014-04-30 06:21:27 (1 comments, 0 reshares, 4 +1s)

A rising tide: the case against Canada as a world citizen

Climate, asbestos, NGOs, muzzled scientists, freedom of information. A lot of hits in a short piece. 

A rising tide: the case against Canada as a world citizen

Climate, asbestos, NGOs, muzzled scientists, freedom of information. A lot of hits in a short piece. ___

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2014-04-28 19:59:05 (0 comments, 2 reshares, 2 +1s)

Updated GenomeBrowse

Hey, this is interesting.  Golden Helix's free GenomeBrowse has been updated with a bunch of new features.  The one that most caught my eye was that they have added +Evernote integration.  What a great idea!

Updated GenomeBrowse

Hey, this is interesting.  Golden Helix's free GenomeBrowse has been updated with a bunch of new features.  The one that most caught my eye was that they have added +Evernote integration.  What a great idea!___

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2014-04-28 17:21:19 (0 comments, 0 reshares, 0 +1s)

Really nice story about a really nice guy.  Ten years out from glioblastoma is amazing.  The world needs more Yarons in it.

Really nice story about a really nice guy.  Ten years out from glioblastoma is amazing.  The world needs more Yarons in it.___

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2014-04-28 17:19:27 (3 comments, 2 reshares, 6 +1s)

Really nice story about a really nice guy.  Ten years out from glioblastoma is amazing.  The world needs more Yarons in it.

Really nice story about a really nice guy.  Ten years out from glioblastoma is amazing.  The world needs more Yarons in it.___

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2014-04-23 19:07:03 (9 comments, 2 reshares, 9 +1s)

The influenza vaccine is now mandatory for healthcare workers in British Columbia.  This person refused both the vaccine and the alternative (wearing a mask while in contact with patients) and so has been fired.

The influenza vaccine is now mandatory for healthcare workers in British Columbia.  This person refused both the vaccine and the alternative (wearing a mask while in contact with patients) and so has been fired.___

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2014-04-15 20:40:35 (4 comments, 6 reshares, 16 +1s)

tl;dr Wikipedia

http://tldrwikipedia.tumblr.com/

tl;dr Wikipedia

http://tldrwikipedia.tumblr.com/___

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2014-04-07 05:47:47 (3 comments, 22 reshares, 76 +1s)

Nicely said, +Cara Santa Maria. 

Nicely said, +Cara Santa Maria. ___

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2014-04-01 20:51:23 (6 comments, 0 reshares, 0 +1s)

Review of Mammography studies: benefits versus harms

This is a big (open access) review of 50 years of studies on the benefits versus harms of #mammography  in #breast   #cancer  screening.  The authors find a 19% reduction in breast cancer mortality (15%/32% for women in their 40s/60s).  They also estimate that a women in her 40s/50s who undergoes 10 years of mammograms is at a 61% risk for receiving a false-positive result.

Much has been made lately about the disagreement over mammography screening recommendations, and this study seems to find the same issues (although I haven't read through it all yet).  Namely, mammograms can find more cancers and at earlier stages, meaning that they can be treated earlier thus improving mortality.  But the screening comes at a cost of the risk for false-positives, which this study shows is non-trivial.  Weighing the balance ofthese b... more »

Review of Mammography studies: benefits versus harms

This is a big (open access) review of 50 years of studies on the benefits versus harms of #mammography  in #breast   #cancer  screening.  The authors find a 19% reduction in breast cancer mortality (15%/32% for women in their 40s/60s).  They also estimate that a women in her 40s/50s who undergoes 10 years of mammograms is at a 61% risk for receiving a false-positive result.

Much has been made lately about the disagreement over mammography screening recommendations, and this study seems to find the same issues (although I haven't read through it all yet).  Namely, mammograms can find more cancers and at earlier stages, meaning that they can be treated earlier thus improving mortality.  But the screening comes at a cost of the risk for false-positives, which this study shows is non-trivial.  Weighing the balance of these benefits and harms is difficult for individual patient recommendations, and essentially impossible to do well on a population scale recommendation.

The authors end with a reasonable suggestion: To maximize the benefit of mammography screening, decisions should be individualized based on patients’ risk profiles and preferences.___

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2014-03-31 07:44:12 (1 comments, 0 reshares, 6 +1s)

So my ongoing irritation with a group I used to support--the +Union of Concerned Scientists --has resulted in a rant that has found a home.

And I'm letting the cat shred the last membership renewal letter which ironically arrived yesterday while I was writing it. They won't be getting my support anymore unless they rethink their plant science division.

Thanks to +Fourat Janabi for a space to vent.

#GMO  

So my ongoing irritation with a group I used to support--the +Union of Concerned Scientists --has resulted in a rant that has found a home.

And I'm letting the cat shred the last membership renewal letter which ironically arrived yesterday while I was writing it. They won't be getting my support anymore unless they rethink their plant science division.

Thanks to +Fourat Janabi for a space to vent.

#GMO  ___

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2014-03-30 06:01:55 (3 comments, 0 reshares, 11 +1s)

Bic pens for Women

They're practically indestructible, so they'll stand up to all of your mood swings. 

Bic pens for Women

They're practically indestructible, so they'll stand up to all of your mood swings. ___

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2014-03-28 18:16:46 (0 comments, 0 reshares, 1 +1s)

The validation cohort should be easy to assemble for this, although I think simple phenotyping would be sufficient in most cases and much cheaper.

The validation cohort should be easy to assemble for this, although I think simple phenotyping would be sufficient in most cases and much cheaper.___

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2014-03-27 15:00:41 (0 comments, 0 reshares, 3 +1s)

For my column this week in the New York Times, I look at how machine learning (think Watson on Jeopardy) can help doctors swim through the ocean of cancer data and come up with better treatments.

http://www.nytimes.com/2014/03/27/science/enlisting-a-computer-to-battle-cancers-one-by-one.html?hp

For my column this week in the New York Times, I look at how machine learning (think Watson on Jeopardy) can help doctors swim through the ocean of cancer data and come up with better treatments.

http://www.nytimes.com/2014/03/27/science/enlisting-a-computer-to-battle-cancers-one-by-one.html?hp___

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2014-03-25 20:17:20 (0 comments, 0 reshares, 5 +1s)

Quacks and fringe loonies upset that Wikipedia continues to label #CAM practitioners as quacks and fringe loonies.

Quacks and fringe loonies upset that Wikipedia continues to label #CAM practitioners as quacks and fringe loonies.___

2014-03-23 06:45:48 (0 comments, 0 reshares, 1 +1s)

Join us for a Science on Google+ HOA as we speak to +Akinola Emmanuel and Dr +shilpa keerthivasan about their recently published research on cancer signalling (http://stm.sciencemag.org/content/6/225/225ra28). We will discuss the basics of cancer signalling, explain the link between inflammation and cancer, and how their research identifies a novel role for immune cells in the development of colon cancer. This Pub Talks HOA will be part of a series in which we explain published research in a jargon-free manner that is understandable to the public.

This HOA will be hosted by Dr +Buddhini Samarasinghe and you can tune in on Sunday March 23rd at 2 PM CDT/ 12PM PDT/ 7 PM GMT. The hangout will be available for viewing on our YouTube channel (https://www.youtube.com/ScienceHangouts) after the event.

Join us for a Science on Google+ HOA as we speak to +Akinola Emmanuel and Dr +shilpa keerthivasan about their recently published research on cancer signalling (http://stm.sciencemag.org/content/6/225/225ra28). We will discuss the basics of cancer signalling, explain the link between inflammation and cancer, and how their research identifies a novel role for immune cells in the development of colon cancer. This Pub Talks HOA will be part of a series in which we explain published research in a jargon-free manner that is understandable to the public.

This HOA will be hosted by Dr +Buddhini Samarasinghe and you can tune in on Sunday March 23rd at 2 PM CDT/ 12PM PDT/ 7 PM GMT. The hangout will be available for viewing on our YouTube channel (https://www.youtube.com/ScienceHangouts) after the event.___

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2014-03-21 14:11:33 (1 comments, 0 reshares, 6 +1s)

A great post that +Rajini Rao wrote for last year's World Down Syndrome Day.

Down Syndrome Day

Today, 3/21, is World Down Syndrome Day. Also known as Trisomy 21, because it involves three copies of chromosome 21 instead of the usual two (see image), Down syndrome is the most complex of genetic disorders that is compatible with survival (other trisomies are more common, but are lethal). Even Down syndrome is associated with ~50% lethality of embryos. In the US, 1 in 691 babies is born with Down syndrome.

Too much of a good thing: Anywhere from 300 to 500 genes have altered levels and function, resulting 80 or 90 possible symptoms and an instantly recognizable phenotype (physical appearance). For example, patients have a 1 in 5 chance of developing a hole in the heart, compared to an incidence of 1:10,000 in the normal population. Down syndrome is extraordinarily complex, and my friend and colleague Roger Reeves has dedicated his career to helping patients with his research.

Cerebellar size: Dr. Reeves showed that the reduced size of the cerebellum in patients was due to defects in the sonic hedgehog signaling pathway. Using a drug that activated this pathway, he was able to restore the number of cerebellar cells to normalcy in a mouse model of Down syndrome, pointing to a therapeutic potential for the central nervous system deficits in patients.

Tweaking circuits: In the hippocampus—that part of the brain that’s used to navigate landmarks and fix memories, Down syndrome patients show an excess of inhibitory pathways compared to excitatory ones. A drug that is already FDA-approved works wonders on mice with the equivalent of Down syndrome, restoring balance to their brain. This drug is now in clinical trials for  Down syndrome patients.

It's not all bad: Research on Down syndrome has broad impact. For example, having three copies of a tumor suppressor gene means that patients have a 93% lower incidence of developing certain cancers. This insight could help treat cancers in the general population. Plus, as Roger likes to say, if you know anyone with Down syndrome, they tend to be pretty interesting individuals in their own right.

For more on Roger's research: http://goo.gl/uSJWm

#ScienceEveryday #DownSyndrome  ___A great post that +Rajini Rao wrote for last year's World Down Syndrome Day.

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2014-03-19 17:06:16 (2 comments, 10 reshares, 9 +1s)

Frequent DNA repair gene mutation in familial prostate cancer

Prostate cancer is known to have a familial component (it is sometimes observed to run in families) but genes associated with hereditary risk for prostate cancer are few.  One exception is the increased risk for prostate cancer in BRCA2 mutation carriers, which is why prostate cancer is considered informative when assessing hereditary breast and ovarian cancer families.  But there is more heritability out there to be found, and because of BRCA2's role the authors of this study decided to look at other DNA repair genes.

The patients in this study all had family history of prostate cancer (>= 3 PrCa cases in family) and most had at least one relative affected with breast, ovarian or colorectal cancer.

What's the summary of their findings? They analysed the coding sequences of 22 tumour suppressorg... more »

Frequent DNA repair gene mutation in familial prostate cancer

Prostate cancer is known to have a familial component (it is sometimes observed to run in families) but genes associated with hereditary risk for prostate cancer are few.  One exception is the increased risk for prostate cancer in BRCA2 mutation carriers, which is why prostate cancer is considered informative when assessing hereditary breast and ovarian cancer families.  But there is more heritability out there to be found, and because of BRCA2's role the authors of this study decided to look at other DNA repair genes.

The patients in this study all had family history of prostate cancer (>= 3 PrCa cases in family) and most had at least one relative affected with breast, ovarian or colorectal cancer.

What's the summary of their findings? They analysed the coding sequences of 22 tumour suppressor genes in 191 familial PrCa cases in the United Kingdom and found that 7.3% (14 of 191) of these cases were carriers of a putative LoF [loss of function] mutation.  The breakdown of the mutation is in the chart below, and you can see the whole list of their 22 gene panel in the full paper.

Also, and perhaps more importantly, they found that LoF mutation carriers were more likely to have advanced disease, defined by nodal involvement, metastasis or primary tumour grade of T4 (OR 15.09, 95% CI: 2.95–95.81, P=0.00164)  An odds ratio of 15 is huge (although note that you could drive a truck through the confidence interval).

So, individuals with prostate cancer, who have a family history of the disease and who carry germline (i.e. inherited) mutations in DNA repair genes, are more likely to present with advanced disease.  

It's an interesting study. So how it is useful?  Well, for one thing it gives some support to thinking about screening men with increased risk for some of these mutations.  Men with a significant family history and a mutation could receive increased surveillance to try and detect early signs of disease.  

Check it out at the open access link below:

http://www.nature.com/bjc/journal/v110/n6/full/bjc201430a.html___

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2014-03-17 19:25:21 (0 comments, 2 reshares, 7 +1s)

You want to see the human side of science? This video shows it in beautiful clarity. This is hands down my favorite science video ever.

You want to see the human side of science? This video shows it in beautiful clarity. This is hands down my favorite science video ever.___

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2014-03-16 22:02:36 (0 comments, 0 reshares, 0 +1s)

Had not realized that NVIC and Mercola were both financed by Mercola's Health Liberty coalition: http://scienceblogs.com/aetiology/2014/03/16/nvic-and-mercola-sittin-in-a-tree/

Had not realized that NVIC and Mercola were both financed by Mercola's Health Liberty coalition: http://scienceblogs.com/aetiology/2014/03/16/nvic-and-mercola-sittin-in-a-tree/___

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2014-03-13 20:12:15 (0 comments, 1 reshares, 7 +1s)

A great post from +Tara C. Smith, someone who truly understands how vaccines work, about why she vaccinates her own children.  Follow the link to read why (and to see pictures of her absolutely adorable little boy).

A great post from +Tara C. Smith, someone who truly understands how vaccines work, about why she vaccinates her own children.  Follow the link to read why (and to see pictures of her absolutely adorable little boy).___

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