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Dee Solberg

Dee Solberg 

Writer, mom, veteran, space nut, gardener, yarn and material hog...

Occupation: Self Employed

Followers: 26,536

Following: 3,061

Views: 1,663,836

Added to CircleCount.com: 01/11/2012That's the date, where Dee Solberg has been indexed by CircleCount.com.
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Dee Solberg has been at 2 events

HostFollowersTitleDateGuestsLinks
R.J. Blain14,845You're invited to join me on my website, on the plus, facebook, and twitter -- all of the interwebs!! -- for the launch party of my newest urban fantasy thriller release, Inquisitor! It also just happens to be my virtual birthday bash too! For more information: http://rjblain.com/2014/05/youre-invited/ If you use facebook, you can invite your friends here: https://www.facebook.com/events/231773600349858/ For those on twitter, follow me and watch for the shenanigans here: https://twitter.com/rj_blain Thank you so much for your support!Inquisitor Launch Party2014-05-16 14:00:0013  
Matthew Graybosch19,604Please join me as I reveal the new cover for my first novel, _Without Bloodshed_ (Part One of Starbreaker), available in electronic and paperback formats on *Sunday, 17 November 2013*. Tell your friends. In addition to revealing the cover, I'll be reading excerpts from my novel if I can get hangouts working on my computer, and answering any questions you might have about +Starbreaker -- as long as it doesn't involve spoilers. It's gonna be a black Sabbath. Join me, or carry your regret to your grave! #starbreaker #revelation #release  Without Bloodshed - Cover Revelation2013-11-03 15:00:0053  

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Activity

Average numbers for the latest posts (max. 50 posts, posted within the last 4 weeks)

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reshares per post
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Top posts in the last 50 posts

Most comments: 37

2016-03-20 21:25:19 (37 comments; 0 reshares; 11 +1s; )Open 

Evidently Samsung appliances are junk.  We bought all new appliances two years ago for our anniversary.  The dishwasher, stove, and fridge are all now having issues.  The dishwasher I'm fairly certain is just plain dead unless we want to pay more to repair this one than it would take to buy a new one.  The fridge is leaking in the door and freezing in the bottom of the freezer and causing damage to the floor underneath as well.  When called, no help.  I Googled commonly known issues with the appliances and found all sorts of Known issues that weren't listed when we bought the appliances via Consumer Affairs (452 complaints in just recent times).  The stove has a convection oven that the fan is now trying to die on.  All at once.  Maybe Tanked will make aquariums for us out of them... #crapappliances   #samsungcrap  

Most reshares: 6

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2016-03-26 04:28:00 (6 comments; 6 reshares; 26 +1s; )Open 

Goodnight Googalia.  I hope you're doing well.  Tax time approaches, political nightmares abound, and well...the meter man he can't cope with one itsy bitsy spider...

Most plusones: 50

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2016-04-10 03:18:27 (21 comments; 1 reshares; 50 +1s; )Open 

Sniff. Mah baby is all growed up and going to prom. +Taylor Solberg​ turned 17 yesterday and she took the ACT and now is dancing with her buddies.

Latest 50 posts

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2016-07-27 04:26:01 (3 comments; 0 reshares; 4 +1s; )Open 

Warning: Political Satire. #redactedtonight  

Warning: Political Satire. #redactedtonight  ___

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2016-07-04 12:52:07 (0 comments; 0 reshares; 6 +1s; )Open 

Good morning Googalia. How are you? If you're American, Happy 4th. If you aren't, have a great day/evening.

How to cook Grains..___Good morning Googalia. How are you? If you're American, Happy 4th. If you aren't, have a great day/evening.

2016-07-04 03:38:53 (4 comments; 0 reshares; 18 +1s; )Open 

My daughter and I went to eat out yesterday a sort of "girls" day. One of the waitresses had hair that was obviously well cared for and looked as if she were about to step out onto a ballet stage...beautiful. Do you know what was sad? The look of astonishment and disbelief that she got when I told her so. When she saw I was serious, she wasn't sure what to do. I hadn't meant to embarrass her, just let her know I'd noticed her beautiful artistic hair. Obviously the people around the woman in her personal life aren't giving her enough compliments or something.

My daughter and I went to eat out yesterday a sort of "girls" day. One of the waitresses had hair that was obviously well cared for and looked as if she were about to step out onto a ballet stage...beautiful. Do you know what was sad? The look of astonishment and disbelief that she got when I told her so. When she saw I was serious, she wasn't sure what to do. I hadn't meant to embarrass her, just let her know I'd noticed her beautiful artistic hair. Obviously the people around the woman in her personal life aren't giving her enough compliments or something.___

2016-06-28 12:40:18 (0 comments; 0 reshares; 7 +1s; )Open 

RIP Pat Summit. You were a class act.

RIP Pat Summit. You were a class act.___

2016-06-27 21:52:59 (30 comments; 0 reshares; 5 +1s; )Open 

Do you believe in coincidences?

Do you believe in coincidences?___

2016-06-22 03:14:50 (2 comments; 0 reshares; 8 +1s; )Open 

Yes...me too baby.

Today is national yoga day, so later I will be celebrating it by performing the corpse pose XD___Yes...me too baby.

2016-06-13 18:09:44 (4 comments; 0 reshares; 14 +1s; )Open 

It's funny how hospital billing departments tell you they are sorry, there's nothing they can do to help you figure out the double billing issues, then can act so hurt when you let them know that all receipts and bills will be then forwarded to the insurance company to sort out who is committing the fraud. I have been billed twice for an MRI, and twice for the reading of the same MRI. One from each department. Well, I called both departments regarding the issue and asked them directly, then asked if they could investigate...neither was willing to help me, both acted horrified and hurt that I would turn this in to my insurance company to be resolved...I mean if I was double billed, likely my insurance company was also since the payments from them are listed on the bills. So, NOW the billing operator was like, "You didn't give us a chance to help you..." Me: I called, asked the... more »

It's funny how hospital billing departments tell you they are sorry, there's nothing they can do to help you figure out the double billing issues, then can act so hurt when you let them know that all receipts and bills will be then forwarded to the insurance company to sort out who is committing the fraud. I have been billed twice for an MRI, and twice for the reading of the same MRI. One from each department. Well, I called both departments regarding the issue and asked them directly, then asked if they could investigate...neither was willing to help me, both acted horrified and hurt that I would turn this in to my insurance company to be resolved...I mean if I was double billed, likely my insurance company was also since the payments from them are listed on the bills. So, NOW the billing operator was like, "You didn't give us a chance to help you..." Me: I called, asked the question, paid the bill, you informed me there was nothing you were able to do. If there IS something you can do, please say so and I'll await a call. Them: But there isn't anything we can do, we did the work! Me: That's between you and the Neurology clinic that also collected. Them: But that's not fair! Me: Neither is double billing clients and giving them no other options. Have a nice day, you'll be hearing from my insurance company soon I'm sure.___

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2016-06-13 17:22:22 (3 comments; 0 reshares; 17 +1s; )Open 

It's been a while since I've posted something beautiful by a long standing artist and fellow Googalian. This photo by +Linda Stokes just speaks to my soul. If I can, I'm going to buy a print of this because the simple beauty is beyond stunning.

Happy #monday   #mondayblues   #beautifulnature   #mundanemonday   #flowers   #flowerphotography   #lotus   #blue  ___It's been a while since I've posted something beautiful by a long standing artist and fellow Googalian. This photo by +Linda Stokes just speaks to my soul. If I can, I'm going to buy a print of this because the simple beauty is beyond stunning.

2016-06-10 17:32:36 (4 comments; 0 reshares; 5 +1s; )Open 

Hey you smart Googaliens, is there any such thing as underwater headphones for swimmers? Because that would be wicked. If there isn't, there should be, you're welcome for the idea ;P

Hey you smart Googaliens, is there any such thing as underwater headphones for swimmers? Because that would be wicked. If there isn't, there should be, you're welcome for the idea ;P___

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2016-05-31 00:20:36 (11 comments; 3 reshares; 19 +1s; )Open 

Via +Timmy Timtim 


There goes my weight watcher points just watching this!

Deep-Fried Deviled Eggs, TASTY!

12 peeled hard-boiled eggs
1 cup flour
3 eggs
1 cup panko bread crumbs
 Oil for frying
4 Tbsp. mayonnaise
2 Tbsp. pickle relish
2 Tbsp. mustard
 1 tsp hot sauce
 Salt to taste Pepper to taste
Optional:
 * Paprika, or seasoning of choice to top Directions: Heat cooking oil for deep-frying in a medium-size pan over medium heat. Cut the hard-boiled eggs in half lengthwise. Gently separate the cooked egg white from the yolk and remove to a medium bowl. Coat the cooked egg white in flour, eggs, and panko bread crumbs. Carefully place eggs into the hot oil. Fry for 2-3 minutes, flipping halfway through. Remove from pan and drain excess oil on a paper towel. Add mayonnaise, relish, mustard, hot sauce, salt, and pepper to the yolks and mash until smooth. Fill a piping bag or plastic sandwich bag with yolk mixture. Pipe mixture back into the fried egg white, dust with paprika, and serve!___Via +Timmy Timtim 


There goes my weight watcher points just watching this!

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2016-05-17 02:37:43 (11 comments; 0 reshares; 39 +1s; )Open 

I decided whacking about 4 inches off my hair seemed like a good idea today.

I decided whacking about 4 inches off my hair seemed like a good idea today.___

2016-05-12 03:11:54 (10 comments; 0 reshares; 10 +1s; )Open 

How's this for a personality quirk? I have a hard time with major dates...as in remembering them. I can remember stuff happening, but those people who can tell you dates? Yeah, that isn't me. I can tell you exactly where I was, what I was doing when Reagan was shot, when the Challenger blew up, when other major events occurred, but as for the date? Nope. I'm flawed I think.

How's this for a personality quirk? I have a hard time with major dates...as in remembering them. I can remember stuff happening, but those people who can tell you dates? Yeah, that isn't me. I can tell you exactly where I was, what I was doing when Reagan was shot, when the Challenger blew up, when other major events occurred, but as for the date? Nope. I'm flawed I think.___

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2016-05-12 02:04:54 (0 comments; 0 reshares; 6 +1s; )Open 

+Pam Adger or your cat can do this... :D

+Pam Adger or your cat can do this... :D___

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2016-05-04 06:54:05 (6 comments; 0 reshares; 6 +1s; )Open 

Ramifications? Ethics discussion? Keep it polite.

Ramifications? Ethics discussion? Keep it polite.___

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2016-05-03 01:36:17 (7 comments; 0 reshares; 8 +1s; )Open 

For those who believe Trump should do more to disavow the KKK...Here is a little reading for you, and heads up...Snopes is being rather misleading and I find it interesting they are doing so, so obviously.  My question is, where is the outrage about the support of the Klan for Hillary?  It's spot on for Trump, but in light of the articles listed below, I kind of think her support from the Klan weighs rather heavier.  It's something to consider.  

For the record, I detest BOTH candidates equally and with fervor.


http://www.telegraph.co.uk/news/worldnews/northamerica/usa/12192975/The-KKK-leader-who-says-he-backs-Hillary-Clinton.html

http://www.anonews.co/hillary-clinton-kkk/

http://www.huffingtonpost.com/entry/hillary-clinton-kkk_us_56e7373ae4b0b25c918304f2

http://www.vocativ.com/312479/kkk-endorses-hillary-clinton-for-president/

For those who believe Trump should do more to disavow the KKK...Here is a little reading for you, and heads up...Snopes is being rather misleading and I find it interesting they are doing so, so obviously.  My question is, where is the outrage about the support of the Klan for Hillary?  It's spot on for Trump, but in light of the articles listed below, I kind of think her support from the Klan weighs rather heavier.  It's something to consider.  

For the record, I detest BOTH candidates equally and with fervor.


http://www.telegraph.co.uk/news/worldnews/northamerica/usa/12192975/The-KKK-leader-who-says-he-backs-Hillary-Clinton.html

http://www.anonews.co/hillary-clinton-kkk/

http://www.huffingtonpost.com/entry/hillary-clinton-kkk_us_56e7373ae4b0b25c918304f2

http://www.vocativ.com/312479/kkk-endorses-hillary-clinton-for-president/___

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2016-05-01 14:03:37 (4 comments; 0 reshares; 22 +1s; )Open 

So this was my weekend...

#martialarts   #sparring   #RDMA  

So this was my weekend...

#martialarts   #sparring   #RDMA  ___

2016-04-24 02:38:46 (4 comments; 0 reshares; 2 +1s; )Open 

Can anyone help a girl out?

OK, I'm in the process of learning Korean. So I don't know how to spell very well. Does anyone know how to spell "Faye" in Hangul?___Can anyone help a girl out?

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2016-04-13 03:37:13 (6 comments; 2 reshares; 17 +1s; )Open 

+R.J. Blain I saw this and thought of you and your love for pens...

+R.J. Blain I saw this and thought of you and your love for pens...___

2016-04-13 01:39:47 (14 comments; 0 reshares; 2 +1s; )Open 

Okay, time for some Google help if you guys can spare it.  My daughter has to try and make a bar graph from blood pressures she collected in an experiment and she did her tables in Google Spreadsheet.  Is there a way to dump them into a bar graph or any graph easily?  TIA!

Okay, time for some Google help if you guys can spare it.  My daughter has to try and make a bar graph from blood pressures she collected in an experiment and she did her tables in Google Spreadsheet.  Is there a way to dump them into a bar graph or any graph easily?  TIA!___

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2016-04-10 03:18:27 (21 comments; 1 reshares; 50 +1s; )Open 

Sniff. Mah baby is all growed up and going to prom. +Taylor Solberg​ turned 17 yesterday and she took the ACT and now is dancing with her buddies.

Sniff. Mah baby is all growed up and going to prom. +Taylor Solberg​ turned 17 yesterday and she took the ACT and now is dancing with her buddies.___

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2016-04-07 18:28:55 (1 comments; 0 reshares; 3 +1s; )Open 

What a sumptuous feast of words. Makes me feel downright ebullient!

Do you have a favorite word? Or one you'd add?

http://karaspartyideas.com

#ThesaurusThursday

What a sumptuous feast of words. Makes me feel downright ebullient!

Do you have a favorite word? Or one you'd add?

http://karaspartyideas.com

#ThesaurusThursday___

2016-04-06 00:57:28 (15 comments; 0 reshares; 6 +1s; )Open 

A synonym, one word for the phrase, richer than life.

A synonym, one word for the phrase, richer than life.___

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2016-04-05 18:50:27 (0 comments; 0 reshares; 5 +1s; )Open 

Once the science is vetted on this, this could very well be the breakthrough of the decade, possibly even bigger.  

Once the science is vetted on this, this could very well be the breakthrough of the decade, possibly even bigger.  ___

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2016-04-03 04:29:16 (9 comments; 0 reshares; 17 +1s; )Open 

The cat glued to my side in my messy chair. He got mad at the kids for carting him off to bed. The second I close the laptop, he'll be running to his food so I can watch him eat. Piggy is a good cat when he doesn't pee on stuff.

The cat glued to my side in my messy chair. He got mad at the kids for carting him off to bed. The second I close the laptop, he'll be running to his food so I can watch him eat. Piggy is a good cat when he doesn't pee on stuff.___

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2016-04-03 04:02:52 (2 comments; 0 reshares; 6 +1s; )Open 

LOVE these Greek Brown Rice Bowls!
RECIPE: http://www.runningtothekitchen.com/greek-brown-rice-bowls/

LOVE these Greek Brown Rice Bowls!
RECIPE: http://www.runningtothekitchen.com/greek-brown-rice-bowls/___

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2016-04-03 04:00:26 (0 comments; 0 reshares; 5 +1s; )Open 

Thai Chicken Zucchini Noodle Salad with a Sesame Vinaigrette done in 15 minutes and only 324 calories. Served cold with raw zucchini noodles, refreshing, light, & filled with bold flavors!
Recipe -> http://www.joyfulhealthyeats.com/thai-chicken-zucchini-noodle-salad-with-sesame-vinaigrette/

Thai Chicken Zucchini Noodle Salad with a Sesame Vinaigrette done in 15 minutes and only 324 calories. Served cold with raw zucchini noodles, refreshing, light, & filled with bold flavors!
Recipe -> http://www.joyfulhealthyeats.com/thai-chicken-zucchini-noodle-salad-with-sesame-vinaigrette/___

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2016-04-03 03:57:09 (1 comments; 0 reshares; 4 +1s; )Open 

I must be hungry...

Falling in love with this delicious spring salad all over again! It's a lovely mix of quinoa with roasted radishes and asparagus, fresh garlic and a herby lemon dressing. If you haven't tried it, you must.

Get the recipe here: www.eatingbirdfood.com/spring-quinoa-salad/___I must be hungry...

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2016-04-03 03:19:39 (1 comments; 0 reshares; 9 +1s; )Open 

This sounded good.  I'm not generally a fan of fruit in the main meal but this just tickled the imagination.

Avocado, Mango and Pineapple Quinoa Salad

http://wendypolisi.com/avocado-mango-and-pineapple-quinoa-salad/___This sounded good.  I'm not generally a fan of fruit in the main meal but this just tickled the imagination.

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2016-03-31 03:48:31 (1 comments; 1 reshares; 12 +1s; )Open 

This looks delicious!

Grilled Salmon Kebabs – SO good, now that the weather is warming this will be going on my meal plan... perfect served with a big salad for a light, healthy meal.

http://www.skinnytaste.com/these-lovely-grilled-salmon-and-lemon/___This looks delicious!

2016-03-29 17:35:30 (4 comments; 0 reshares; 4 +1s; )Open 

Morning Googalia.  So I'm having difficulty with my browser opening in one aspect of my monitor and the rest of my stuff opening in another...I think it's VGA and DMI but I'll have to go back and look.  When I logged out Sunday it was working fine.  Ideas?  How do I get it all back on one setting on the monitor?

Morning Googalia.  So I'm having difficulty with my browser opening in one aspect of my monitor and the rest of my stuff opening in another...I think it's VGA and DMI but I'll have to go back and look.  When I logged out Sunday it was working fine.  Ideas?  How do I get it all back on one setting on the monitor?___

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2016-03-29 04:21:28 (17 comments; 1 reshares; 11 +1s; )Open 

Hi everyone!  I have a favor to ask.  I'm wondering if some of you would be willing to send a card or letter to my gramps.  He's turning 94 and he is an old WWII veteran.  No pressure, no drama, just if you want and can do it, it'd be fun to do a round of cards for him like my grandmother (his wife) a couple of years ago.  It would go a ways to perk him up if you can do it.  If you are interested, message me for an address and I am eternally grateful in advance.  

Hi everyone!  I have a favor to ask.  I'm wondering if some of you would be willing to send a card or letter to my gramps.  He's turning 94 and he is an old WWII veteran.  No pressure, no drama, just if you want and can do it, it'd be fun to do a round of cards for him like my grandmother (his wife) a couple of years ago.  It would go a ways to perk him up if you can do it.  If you are interested, message me for an address and I am eternally grateful in advance.  ___

2016-03-29 00:10:44 (15 comments; 0 reshares; 4 +1s; )Open 

It seems more and more the burden of proof is on the person accused rather than the folks making the allegations.  Right or wrong?  This can be for politics, social situations, etc.  I'd love any expanded answers you have to give as well...just stay polite is all I ask. 

It seems more and more the burden of proof is on the person accused rather than the folks making the allegations.  Right or wrong?  This can be for politics, social situations, etc.  I'd love any expanded answers you have to give as well...just stay polite is all I ask. ___

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2016-03-28 21:41:04 (2 comments; 0 reshares; 10 +1s; )Open 

Interesting times!

Stem Cells Help Regenerate Lost Tissue Following Corticospinal Injury

For first time, researchers show functional benefit in animal model of key motor control system.

The research is in Nature Medicine. (full access paywall)

#neurology #genetics___Interesting times!

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2016-03-26 04:28:00 (6 comments; 6 reshares; 26 +1s; )Open 

Goodnight Googalia.  I hope you're doing well.  Tax time approaches, political nightmares abound, and well...the meter man he can't cope with one itsy bitsy spider...

Goodnight Googalia.  I hope you're doing well.  Tax time approaches, political nightmares abound, and well...the meter man he can't cope with one itsy bitsy spider...___

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2016-03-22 14:07:41 (4 comments; 0 reshares; 14 +1s; )Open 

Some days I feel like I'm sitting and spinning, but I know I've made progress...just couldn't tell you what...kind of like resetting the passwords, you got somewhere, you just aren't sure where haha.

Some days I feel like I'm sitting and spinning, but I know I've made progress...just couldn't tell you what...kind of like resetting the passwords, you got somewhere, you just aren't sure where haha.___

2016-03-20 21:25:19 (37 comments; 0 reshares; 11 +1s; )Open 

Evidently Samsung appliances are junk.  We bought all new appliances two years ago for our anniversary.  The dishwasher, stove, and fridge are all now having issues.  The dishwasher I'm fairly certain is just plain dead unless we want to pay more to repair this one than it would take to buy a new one.  The fridge is leaking in the door and freezing in the bottom of the freezer and causing damage to the floor underneath as well.  When called, no help.  I Googled commonly known issues with the appliances and found all sorts of Known issues that weren't listed when we bought the appliances via Consumer Affairs (452 complaints in just recent times).  The stove has a convection oven that the fan is now trying to die on.  All at once.  Maybe Tanked will make aquariums for us out of them... #crapappliances   #samsungcrap  

Evidently Samsung appliances are junk.  We bought all new appliances two years ago for our anniversary.  The dishwasher, stove, and fridge are all now having issues.  The dishwasher I'm fairly certain is just plain dead unless we want to pay more to repair this one than it would take to buy a new one.  The fridge is leaking in the door and freezing in the bottom of the freezer and causing damage to the floor underneath as well.  When called, no help.  I Googled commonly known issues with the appliances and found all sorts of Known issues that weren't listed when we bought the appliances via Consumer Affairs (452 complaints in just recent times).  The stove has a convection oven that the fan is now trying to die on.  All at once.  Maybe Tanked will make aquariums for us out of them... #crapappliances   #samsungcrap  ___

2016-03-19 20:35:19 (6 comments; 0 reshares; 4 +1s; )Open 

Anyone have some really good pickled and canned asparagus recipes?  I could really use a few...17lbs of Bountiful Basket worth!  Thanks in advance! 

Anyone have some really good pickled and canned asparagus recipes?  I could really use a few...17lbs of Bountiful Basket worth!  Thanks in advance! ___

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2016-03-14 23:49:12 (8 comments; 0 reshares; 17 +1s; )Open 

Good evening Googalia.  How are you today?  Supper tonight is homemade beef stew and home cooked bread.  Does anyone else use stout in their stew?  I learned that little trick from grandma.  I don't know why, but it adds something to the flavor that can't be had any other way.  I also add a small bit of tomato sauce, but just a bit.  

Good evening Googalia.  How are you today?  Supper tonight is homemade beef stew and home cooked bread.  Does anyone else use stout in their stew?  I learned that little trick from grandma.  I don't know why, but it adds something to the flavor that can't be had any other way.  I also add a small bit of tomato sauce, but just a bit.  ___

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2016-03-06 22:34:01 (1 comments; 0 reshares; 4 +1s; )Open 

I didn't know there was a women's call center for woman veterans.  Interesting.

In 1950, women were 2 percent of the total military force. Currently, women represent 14.5 percent of active duty military, and 18 percent of Guard and Reserve force. Since 2000, the number of women Veterans using VA health care has more than doubled, by 2020, women Veterans are estimated to be 10.5 percent of the total Veterans population.

VA is committed to enhancing our care and services to women Veterans to provide them the high quality care they have earned and deserve.

We have a Women Veteran Call Center 1-855-VA Women (1-855-829-6636) available weekdays 8 a.m. to 10 p.m. and Saturdays 8 a.m. to 6:30 p.m. (all times ET).___I didn't know there was a women's call center for woman veterans.  Interesting.

2016-03-05 23:05:37 (18 comments; 0 reshares; 7 +1s; )Open 

Hmm, wine or caramel whiskey?

Hmm, wine or caramel whiskey?___

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2016-03-04 14:20:33 (14 comments; 0 reshares; 8 +1s; )Open 

Here's the bird. Hope you sleep well. 

Here's the bird. Hope you sleep well. ___

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2016-03-03 03:58:48 (1 comments; 1 reshares; 10 +1s; )Open 

Posted so I can read later, but you can read too if you like.  It's neat to see that massage therapy is starting to gain more study.

Posted so I can read later, but you can read too if you like.  It's neat to see that massage therapy is starting to gain more study.___

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2016-03-03 01:23:27 (0 comments; 0 reshares; 5 +1s; )Open 

Done for Ben Dutter's "Belly of the Beast" RPG: http://www.bendutter.com/sigil-stone-publishing/belly-of-the-beast-rpg/

www.jeffbrowngraphics.com

Done for Ben Dutter's "Belly of the Beast" RPG: http://www.bendutter.com/sigil-stone-publishing/belly-of-the-beast-rpg/

www.jeffbrowngraphics.com___

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2016-02-29 16:44:45 (1 comments; 0 reshares; 2 +1s; )Open 

Good morning Googalia.  How are you today?  Things are running full steam ahead.  Today's offering is some easy listening A Capella via Peter Hollens who still looks just like my baby brother...also named Peter ;)  

One of my all-time favorites from Tarzan with my buddy @bryanlanning - Don't miss this one!___Good morning Googalia.  How are you today?  Things are running full steam ahead.  Today's offering is some easy listening A Capella via Peter Hollens who still looks just like my baby brother...also named Peter ;)  

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2016-02-15 21:58:04 (16 comments; 0 reshares; 17 +1s; )Open 

Soooo this is a thing

Soooo this is a thing___

2016-02-13 03:59:37 (11 comments; 0 reshares; 8 +1s; )Open 

Have you ever started up a business of your own?  Did it take off?  Yes or no?  How fast did you get your start up loan paid off and start earning income?  When did you start thinking about expanding?

Have you ever started up a business of your own?  Did it take off?  Yes or no?  How fast did you get your start up loan paid off and start earning income?  When did you start thinking about expanding?___

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2016-02-09 23:30:49 (1 comments; 0 reshares; 5 +1s; )Open 

Researchers Discover Lipid Link in Inherited Form of Alzheimer's

Australian researchers have found biochemical changes occurring in the blood, in the rare inherited form of Alzheimer's disease. Changes in these fat-like substances, may suggest a method to diagnose all forms of Alzheimer's disease before significant damage to the brain occurs.

The research is in Journal of Alzheimer's Disease. (full access paywall)

#genetics #alzheimers

Researchers Discover Lipid Link in Inherited Form of Alzheimer's

Australian researchers have found biochemical changes occurring in the blood, in the rare inherited form of Alzheimer's disease. Changes in these fat-like substances, may suggest a method to diagnose all forms of Alzheimer's disease before significant damage to the brain occurs.

The research is in Journal of Alzheimer's Disease. (full access paywall)

#genetics #alzheimers___

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2016-02-09 23:30:28 (1 comments; 0 reshares; 6 +1s; )Open 

Predicting Who Will Develop Multiple Sclerosis

New project will investigate the events leading to multiple sclerosis in at at-risk individuals.

The research is in Annals of Neurology. (full access paywall)

#multiplesclerosis

Predicting Who Will Develop Multiple Sclerosis

New project will investigate the events leading to multiple sclerosis in at at-risk individuals.

The research is in Annals of Neurology. (full access paywall)

#multiplesclerosis___

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2016-01-22 21:51:20 (1 comments; 0 reshares; 4 +1s; )Open 

How does neuroblastoma evade immune cells?

✤ Neuroblastoma is a rare type of solid tumour that affects infants and very young children. It grows from nerve cells left over from development in the womb. Normally these cells vanish once they have done their job, and the reasons why they persist and carry on dividing in rare instances to become a cancer remain a mystery.

✤ One of the intriguing features of neuroblastoma is that the tumour creates an environment where the immune system is suppressed. Cancer cells often send out molecules to suppress the immune system, so that they can remain undetected within our bodies.

✤ Which is why immunotherapies, that can 'wake up the immune system', have so much promise. But first, we have to understand exactly how cancer cells suppress the immune system, so that we can develop those newimmun... more »

How does neuroblastoma evade immune cells?

✤ Neuroblastoma is a rare type of solid tumour that affects infants and very young children. It grows from nerve cells left over from development in the womb. Normally these cells vanish once they have done their job, and the reasons why they persist and carry on dividing in rare instances to become a cancer remain a mystery.

✤ One of the intriguing features of neuroblastoma is that the tumour creates an environment where the immune system is suppressed. Cancer cells often send out molecules to suppress the immune system, so that they can remain undetected within our bodies.

✤ Which is why immunotherapies, that can 'wake up the immune system', have so much promise. But first, we have to understand exactly how cancer cells suppress the immune system, so that we can develop those new immunotherapies.

✤ Our immune system is made up of many different types of cells. The most important is type of cell is known as a T-cell. T-cells can act as the soldiers of the immune system, actively engaged in ‘search and destroy’ missions looking for harmful disease-causing enemy cells. Unfortunately cancer cells can ‘hide’ from T-cells by sending out molecules that put these T-cells to sleep, through a process known as immunosuppression.

✤ But what are these molecules, and how do they cause immunosuppression? And most importantly, how can we exploit this knowledge to develop therapies that can re-activate these T cells?

✤ Researchers at the University of Birmingham have found that a molecule called arginine might be involved. Arginine is an amino acid normally found within our cells, and is broken down by an enzyme called arginase. The team discovered that neuroblastoma cells produce a lot of arginase enzyme. It means that in the environment surrounding neuroblastoma cells, known as the tumour microenvironment, arginine levels are very low. This reduced level of arginine is involved in the immunosuppression seen in neuroblastoma tumours. The team also showed that this same mechanism might be involved in immunosuppression in another childhood cancer, called acute myeloid leukaemia (AML).  

✤ So what is the impact of this research? We now know how important it is to regulate arginine levels in the tumour, so that T-cells can remain active. This immunosuppression also affects cell-based therapies, where engineered T cells are injected into patients. So it’s even more important that we make sure that the immunosuppressed tumour microenvironment is addressed before trying out new immunotherapies for treatment.

✤ It is tempting to think of giving arginine supplements to patients, to 'boost their immune system', but there is concern that it might feed tumour growth. A better approach would be to inhibit the activity of the enzyme, arginase. Excitingly, there are several compounds that act on arginase that are going through pre-clinical investigations. When given in combination with existing immunotherapies, these arginase inhibitors could greatly enhance treatment, and so improve patient outcome for the cancers where they work

Full paper: http://cancerres.aacrjournals.org/content/75/15/3043.long

Image credit: Neuroblastoma cell line, Wikipedia (https://en.wikipedia.org/wiki/Neuroblastoma#/media/File:BiggeggSH-SY5Y.jpg)___

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